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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN1547 Sigma-AldrichAnti-CASK Antibody, clone 2G5.1

This Anti-CASK Antibody, clone 2G5.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of CASK.

Anti-CASK Antibody, clone 2G5.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
技术信息

Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: CASK, LIN2 UniProt Number: O14936

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, H	WB, IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN1547
Replaces	MAB5230
Description	Anti-CASK Antibody, clone 2G5.1
Alternate Names	Peripheral plasma membrane protein CASK hCASK Calcium/calmodulin-dependent serine protein kinase Protein lin-2 homolog CASK
Background Information	Peripheral plasma membrane protein CASK (EC 2.7.11.1; UniProt O14936; also known as Calcium/calmodulin-dependent serine protein kinase, Membrane-associated guanylate kinase, hCASK, Protein lin-2 homolog, Trinucleotide repeat containing 8) is encoded by the CASK (also known as CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8) gene (Gene ID 8573) in human. CASK is a membrane-associated guanylate kinase (MAGUK) family member involved in the regulation of cytoskeletal remodeling and cell migration. It consists of a Ca2+-calmodulin kinase, a PDZ, an SH3, and a guanylate kinase domain. CASK localizes at cell–cell adhesion sites, including synaptic junctions, epithelial junctions, and tight junctions, where it is reported to associate with other cell adhesion molecules, such as junctional adhesion molecule (JAM), cadherins, catenins, and syndecan-2. CASK and syndecan-2 expressions are upregulated in colorectal cancer and their upregulation significantly correlates with advanced tumor stage, lymphatic invasion, lymph node metastasis, vascular invasion, liver metastasis, and unresectable metastatic CRC.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-CASK Antibody, clone 2G5.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of CASK.
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected CASK in human kidney cortex tissue.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to an internal fragment within the C-terminal half of human CASK.
Epitope	Internal (C-terminal half)
Clone	2G5.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Rat Human
Species Reactivity Note	Rat, Human. Predicted to react with Mouse based on 100% sequence homology.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_003679
Gene Symbol	CASK LIN2
Purification Method	Protein G Purified
UniProt Number	O14936
Molecular Weight	~115 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in rat brain tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected CASK in 10 µg of rat brain tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN1547	04055977182811

Documentation

Anti-CASK Antibody, clone 2G5.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-CASK Antibody, clone 2G5.1 分析证书

标题	批号
Anti-CASK, clone 2G5.1 - 3432453	3432453
Anti-CASK, clone 2G5.1 - 4113022	4113022
Anti-CASK, clone 2G5.1 -Q2589602	Q2589602
Anti-CASK, clone 2G5.1 -Q2589617	Q2589617

技术信息

标题
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.

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描述

MAB5230

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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