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MABN778 Anti-C9ORF72/C9RANT (poly-GR) Antibody, clone 5A2

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MABN778
100 µg  
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      概述

      Replacement Information

      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN778
      DescriptionAnti-C9ORF72/C9RANT (poly-GR) Antibody, clone 5A2
      Alternate Names
      • c9orf72
      Background InformationHexanucleotide (GGGGCC) repeat expansions in a noncoding region of C9ORF72 are the major genetic cause of FTD and ALS (c9FTD/ALS). The RNA structure of GGGGCC repeats renders these transcripts susceptible to an unconventional mechanism of translation—repeat associated non-ATG (RAN) translation. Translation of the GGGGCC-repeat in all reading frames would result in three dipeptide-repeat (DPR) proteins poly-(Gly-Ala), poly-(Gly-Pro) and poly-(Gly-Arg). poly-GA and poly-GP proteins are extremely hydrophobic and may form intracellular aggregates
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect C9ORF72/C9RANT (poly-GR) using this Anti-C9ORF72/C9RANT (poly-GR) antibody, clone 5A2 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot detected poly-GR inclusions from brain tissues of C9orf72 patients with C9ORF72 hexanucleotide expansion (Mori, K., et al. (2013). Science. 339(6125):1335-1338.).
      Biological Information
      ImmunogenLinear peptide corresponding to Epstein-Barr Virus Nuclear Antigen 2 (ENBA2) containing GR repeat sequence.
      Epitopepoly-GR
      Clone5A2
      Concentration1 mg/mL
      HostRat
      SpecificityThis antibody recognizes C9ORF72/C9RANT (poly-GR) and other proteins containing poly-GR sequence, such as the Epstein Barr virus protein EBNA2
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with all species.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G Purified
      Molecular WeightVariable
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting using GST® fusion proteins with 15 GA, GP, or GR repeats, as well as GST alone without any repeat sequence.

      Western Blotting Analysis: 0.2 μg of this antibody detected 10 μg of GR-GST recombinant protein with 15 GR repeats.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      MABN778 04053252947063

      Documentation

      Anti-C9ORF72/C9RANT (poly-GR) Antibody, clone 5A2 MSDS

      职位

      物料安全数据表 (MSDS) 

      Anti-C9ORF72/C9RANT (poly-GR) Antibody, clone 5A2 分析证书

      标题批号
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3169493 3169493
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3215522 3215522
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3272291 3272291
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3299963 3299963
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3434652 3434652
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3560678 3560678
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3689949 3689949
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3744326 3744326
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3858275 3858275
      Anti-C9ORF72/C9RANT (poly-GR), clone 5A2 - 3890529 3890529

      参考

      参考概述应用品种公共医疗ID
      The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
      Mori, K; Weng, SM; Arzberger, T; May, S; Rentzsch, K; Kremmer, E; Schmid, B; Kretzschmar, HA; Cruts, M; Van Broeckhoven, C; Haass, C; Edbauer, D
      Science (New York, N.Y.)  339  1335-8  2013

      显示摘要
      Immunohistochemistry (Paraffin)Human23393093 23393093