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MABD411 Sigma-AldrichAnti-BMP4 Antibody, clone PA354-16.1.1

This Anti-BMP4 antibody is validated for use in WB, FC, IH for the detection of BMP4.

Anti-BMP4 Antibody, clone PA354-16.1.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Stem Cell Research Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: BMP4, BMP2B, DVR4 UniProt Number: P12644

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概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, FC, IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABD411
Description	Anti-BMP4 Antibody, clone PA354-16.1.1
Alternate Names	Bone morphogenetic protein 4 BMP-4 Bone morphogenetic protein 2B BMP-2B
Background Information	Bone morphogenetic protein 4 (BMP4), also known as Bone morphogenetic protein 4 (BMP-4), Bone morphogenetic protein 2B (BMP-2B), and encoded by the gene name BMP4/ BMP2B/ DVR4, is morphogenetic protein that induces cartilage and bone formation. Similar to other bone morphogenetic proteins, BMP4 has been shown to play an important role in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-BMP4 antibody is validated for use in WB, FC, IH for the detection of BMP4.
Key Applications	Western Blotting Flow Cytometry Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BMP4 in human pancreas tissue. Flow Cytometry Analysis: 1:200 dilution of this antibody from a representative lot detected BMP4 in Caco-2 cells (Data courtesy of Juan Ignacio Imbaud, Protein Alternatives).

Biological Information
Immunogen	MBP-tagged recombinant protein corresponding to human BMP4.
Clone	PA354-16.1.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001193
Gene Symbol	BMP4 BMP2B DVR4
Purification Method	Protein G Purified
UniProt Number	P12644
Molecular Weight	47 kDa calculated. The calculated molecular weight is 47 kDa, however BMP4 has been shown as a ~80 and ~90 kDa band in western blots with the use of a MBP tag.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human recombinant protein BMP4. Western Blotting Analysis: 0.5 µg/mL of this antibody detected 0.01 µg human recombinant protein BMP4.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABD411	04055977116953

Documentation

Anti-BMP4 Antibody, clone PA354-16.1.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-BMP4 Antibody, clone PA354-16.1.1 分析证书

标题	批号
Anti-BMP4, clone PA354-16.1.1 -Q2485589	Q2485589
Anti-BMP4, clone PA354-16.1.1 Monoclonal Antibody	3134651

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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