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MABT95 Sigma-AldrichAnti-Arp2/3 complex Antibody, clone 13C9

Anti-Arp2/3 complex Antibody, clone 13C9 detects level of Arp2/3 complex & has been published & validated for use in WB, IH(P).

Anti-Arp2/3 complex Antibody, clone 13C9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: ARPC3, ARC21 UniProt Number: O15145

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT95
Description	Anti-Arp2/3 complex Antibody, clone 13C9
Alternate Names	Actin-related protein 2/3 complex subunit 3 Arp2/3 complex 21 kDa subunit p21-ARC
Background Information	The Arp2/3 complex, which contains ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC, plays a major role in the regulation of the actin polymerization in the cytoskeleton. Two of complex's seven subunits (ARP2 and ARP3) closely resemble monomeric actin and serve as nucleation sites for new actin filaments. The Arp2/3 complex works in conjunction with an activating nucleation-promoting factor (NPF) to aid in the formation of branched actin networks. The regulation of actin cytoskeleton reorganization is important for processes like cell migration, phagocytosis, and intracellular motility of lipid vesicles.

References

Product Information
Format	Purified
Control	MCF-7 cell lysate
Presentation	Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Arp2/3 complex Antibody, clone 13C9 detects level of Arp2/3 complex & has been published & validated for use in WB, IH(P).
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:5,000 dilution from a representative lot detected Arp2/3 complex in human colorectal cancer and human colon tissues (antibody may need further dilution if staining is too strong - optimal dilution to be determined by the end user).

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to human Arp2/3 complex.
Clone	13C9
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_005710
Entrez Gene Summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined. [provided by RefSeq, Jul 2008].
Gene Symbol	ARPC3 ARC21
Purification Method	Protein G Purified
UniProt Number	O15145
UniProt Summary	FUNCTION: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. SUBUNIT STRUCTURE: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell projection SEQUENCE SIMILARITIES: Belongs to the ARPC3 family.
Molecular Weight	~20 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in MCF-7 cell lysate. Western Blot Analysis: A 1:5,000 dilution of this antibody detected Arp2/3 complex on 10 µg of MCF-7 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABT95	04053252687778

Documentation

Anti-Arp2/3 complex Antibody, clone 13C9 MSDS

职位
物料安全数据表 (MSDS)

Anti-Arp2/3 complex Antibody, clone 13C9 分析证书

标题	批号
Anti-Arp2/3 complex, clone 13C9 - 2388376	2388376
Anti-Arp2/3 complex, clone 13C9 - 2227684	2227684
Anti-Arp2/3 complex, clone 13C9 - 2283905	2283905
Anti-Arp2/3 complex, clone 13C9 - 2562396	2562396
Anti-Arp2/3 complex, clone 13C9 - 3173555	3173555
Anti-Arp2/3 complex, clone 13C9 - 3283230	3283230
Anti-Arp2/3 complex, clone 13C9 - 3432920	3432920
Anti-Arp2/3 complex, clone 13C9 - 3574550	3574550
Anti-Arp2/3 complex, clone 13C9 - 3827479	3827479
Anti-Arp2/3 complex, clone 13C9 - 4076695	4076695

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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