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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABC272 Sigma-AldrichAnti-Annexin VI Antibody, clone 4B11.1

This Anti-Annexin VI Antibody, clone 4B11.1 is validated for use in western blotting & ICC for the detection of Annexin VI.

Anti-Annexin VI Antibody, clone 4B11.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ANXA6, ANX6 UniProt Number: P08133

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, ICC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABC272
Description	Anti-Annexin VI Antibody, clone 4B11.1
Alternate Names	Annexin A6 67 kDa calelectrin Annexin VI Annexin-6 Calphobindin-II CPB-II Chromobindin-20 Lipocortin VI Protein III p68 p70
Background Information	The protein Annexin A6 or alternatively known as 67 kDa calelectrin, Annexin VI, Annexin-6, Calphobindin-II (CPB-II), Chromobindin-20, Lipocortin VI, Protein III, p68, or p70 and encoded by the human gene named ANXA6 or ANX6. Annexin VI is part of a large family of Annexin proteins and shares with the family the ability to bind negatively charged phospholipids in a calcium dependent manner. Localized in the plasma membrane annexins are important in many cellular functions as the provide scaffolds and play roles in vesicle transport, exocytosis, endocytosis and calcium transport and conduction. Recent research indicates that Annexin VI can interact with PKCalpha and EGFR in A431 cells to help regulate the phosphorylation of pY-EGFR and the associated activation of downstream signaling events associated with cancer. Annexin VI in normal tissue is expressed most strongly in myocardial tissue where it associates with sarcomeric α-actinin and is part of the sarcomere structure. Annexin VI also regulates terminal chondrocyte differentiation by modulating key signaling pathway activities.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-Annexin VI Antibody, clone 4B11.1 is validated for use in western blotting & ICC for the detection of Annexin VI.
Key Applications	Western Blotting Immunocytochemistry
Application Notes	Western Blotting Analysis: 1 µg/mL from a representative lot detected Annexin VI in 10 µg of C2C12 cell lysate. Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Annexin VI in HeLa and A431 cells. Alexa Fluor® is a registered trademark of Life Technologies®.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to human Annexin VI.
Clone	4B11.1
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Human Mouse
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001146
Gene Symbol	ANXA6 ANX6
Purification Method	Protein G Purified
UniProt Number	P08133
Molecular Weight	~75 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in SH-SY5Y cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected Annexin VI in 10 µg of SH-SY5Y cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABC272	04053252965302

Documentation

Anti-Annexin VI Antibody, clone 4B11.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-Annexin VI Antibody, clone 4B11.1 分析证书

标题	批号
Anti-Annexin VI, clone 4B11.1 - Q2395224	Q2395224
Anti-Annexin VI, clone 4B11.1 -2668538	2668538

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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