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MABS45 Sigma-AldrichAnti-Annexin A1 Antibody, clone CPTC-ANXA1-2

This Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.

Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Signaling Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: ANXA1, LPC1, ANX1, p35 UniProt Number: P04083

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABS45
Description	Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2
Alternate Names	annexin A1 chromobindin-9 annexin I (lipocortin I) Lipocortin I calpactin-2 Calpactin II annexin-1 Phospholipase A2 inhibitory protein Annexin I Calpactin-2 Annexin-13 Chromobindin-9
Background Information	Annexin A1 (ANXA1) is a calcium and phospholipid binding protein almost entirely restricted to microglia in the CNS. During the peripheral inflammatory response, Annexin A1 is instrumental in the phagocytosis of apoptotic leukocytes. Annexin A1 restores the ability of microglia to differentiate between apoptotic and non-apoptotic cells during inflammatory activation. Current research is geared towards using Annexin A1 as a therapeutic target in neuroinflammation. Annexin A1 has also been shown to be influential in cancer development and proliferation.

References

Product Information
Format	Purified
Control	K562 cell lysate
Presentation	Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-ANXA1-2)

Biological Information
Immunogen	Full length recombinant protein corresponding to human Annexin A1. Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program
Clone	CPTC-ANXA1-2
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000691
Entrez Gene Summary	Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq].
Gene Symbol	ANXA1 LPC1 ANX1 p35
Purification Method	Protein G
UniProt Number	P04083
UniProt Summary	FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity. SUBUNIT STRUCTURE: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection › cilium (By similarity). Basolateral cell membrane (By similarity). Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity). DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid. PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity. SEQUENCE SIMILARITIES: Belongs to the annexin family. Contains 4 annexin repeats.
Molecular Weight	~ 39 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in K562 cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Annexin A1 on 10 µg of K562 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABS45	04053252644870

Documentation

Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 MSDS

职位
物料安全数据表 (MSDS)

Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 分析证书

标题	批号
Anti-Annexin A1, clone CPTC-ANXA1-2 - 2450742	2450742
Anti-Annexin A1, clone -2650874	2650874
Anti-Annexin A1, clone -2673126	2673126
Anti-Annexin A1, clone CPTC-ANXA1-2 - 2051422	2051422
Anti-Annexin A1, clone CPTC-ANXA1-2 - 3660416	3660416
Anti-Annexin A1, clone CPTC-ANXA1-2 - 4048711	4048711
Anti-Annexin A1, clone CPTC-ANXA1-2 - NRG1831974	NRG1831974
Anti-Annexin A1, clone CPTC-ANXA1-2 Monoclonal Antibody	3128123

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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