数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

171610 Sigma-AldrichAnti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb

Anti-Amyloid Precursor Protein, C-Terminal (751-770), rabbit polyclonal, recognizes full-length APP and C-terminal soluble products CTFα, β, and γ. It is validated for WB, IF, IHC, and IP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: Anti-0443, Anti-APP-CT20

Recommended Products

概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
H	Rb	Polyclonal Antibody

价格及供货情况

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Description
Overview	Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa). Antibody Target Gene Symbol: APP Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2 Entrez Gene Name: amyloid beta (A4) precursor protein Hu Entrez ID: 351 (Related Antibodies: PC729, PC152,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537) Mu Entrez ID: 11820 Rat Entrez ID: 54226
Catalogue Number	171610
Brand Family	Calbiochem®
Synonyms	Anti-0443, Anti-APP-CT20

References
References	Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481.

Product Information
Declaration	Purchase of this material is for research use only. Users are invited to request a license from Mayo prior to using the 0433 antibody or any derivatives for clinical diagnostic or therapeutic purposes. For license information, please contact: Mayo Medical Ventures, Office of Technology Commercialization (507) 284-8878, 200 First Street SW, Rochester, MN 55905-001.
Form	Liquid
Quality Level	MQ100

Applications
Key Applications	Immunoblotting (Western Blotting) Immunofluorescence Immunohistochemistry Immunoprecipitation
Application Notes	Immunoblotting (1:5000-1:20,000) Immunofluorescence (1:1000) Immunohistochemistry (1:1000) Immunoprecipitation (1:1000)
Application Comments	Variables associated with assay conditions will dictate the proper working dilution.

Biological Information
Immunogen	a synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
Immunogen	Human
Host	Rabbit
Isotype	IgG
Species Reactivity	Human
Antibody Type	Polyclonal Antibody

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
171610-50ULCN	07790788048150

Documentation

Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb MSDS

职位
物料安全数据表 (MSDS)

Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb 分析证书

标题	批号
171610	输入批号

参考

参考信息概述
Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481.

小册子

标题
Alzheimer's Disease Brochure & Technical Guide

引用

标题

Jonathan D. J. Wrigley, et al. (2005) Functional overexpression of γ-secretase reveals protease independent trafficking functions and a critical role of lipids for protease activity. Journal of Biological Chemistry 280, 12523-12535.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	23-July-2007 RFH
Synonyms	Anti-0443, Anti-APP-CT20
Application	Immunoblotting (1:5000-1:20,000) Immunofluorescence (1:1000) Immunohistochemistry (1:1000) Immunoprecipitation (1:1000)
Description	Rabbit polyclonal antibody supplied as undiluted serum. Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
Background	Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is cleaved by alpha-secretase to generate sAPPα and CTFα, which is the C-terminal membrane, associated product of α-secretase cleavage. α-secretase cleaves in the Aβ domain. β-secretase cleavage of APP at the N-terminal end of the Aβ sequence results in sAPPβ and CTFβ. Both CTFα and CTFβ are cleaved at the C-terminal end of the Aβ transmembrane domain to generate CTFγ. The antibody (171610) detects CTFγ fragment, which migrates at about 6 kDa on SDS-PAGE gels.
Host	Rabbit
Immunogen species	Human
Immunogen	a synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH
Isotype	IgG
Species	human
Form	Liquid
Comments	Variables associated with assay conditions will dictate the proper working dilution.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481.
Citation	Jonathan D. J. Wrigley, et al. (2005) Functional overexpression of γ-secretase reveals protease independent trafficking functions and a critical role of lipids for protease activity. Journal of Biological Chemistry 280, 12523-12535.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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