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CBL56 Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56

Anti-Adrenocorticotropic Hormone Antibody, C-terminus, clone 56 is an antibody against Adrenocorticotropic Hormone for use in ELISA, IH(P).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: CNS Control of Metabolism, Hormones & Receptors Gene Symbol: POMC, pro-ACTH-endorphin, adrenocorticotropin, beta-LPH, POC, gamma-LPH, LPH, ACTH, corticotropin, beta-endorphin, beta-MSH, alpha-MSH, pro-opiomelanocortin, proopiomelanocortin, Pro-opiomelanocortin, corticotropin-lipotrophin, NPP, MSH, met-enkephalin, CLIP, gamma-MSH UniProt Number: P01189
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CBL56
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      特卖

       

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      概述

      特卖

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      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RELISA, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL56
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Adrenocorticotropic Hormone Antibody, CT, clone 56
      Alternate Names
      • ACTH
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 0.1% sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Adrenocorticotropic Hormone Antibody, C-terminus, clone 56 is an antibody against Adrenocorticotropic Hormone for use in ELISA, IH(P).
      Key Applications
      • ELISA
      • Immunohistochemistry (Paraffin)
      Application NotesThis antibody reacts with solid phase ACTH either captured as part of a sandwich or adsorbed as a solid phase antigen and as such is suitable for serum assay development

      The antibody is also reactive on formalin fixed paraffin wax embedded tissue and is therefore suitable for immunocytochemistry

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenACTH-BSA Conjugate
      EpitopeC-terminus
      Clone56
      HostMouse
      SpecificityThis antibody is specific for CLIP (17-39 ACTH) and no cross reaction with Synacthen (1-24 ACTH).

      KNOWN SPECIES CROSS REACTIVITY: Positive with rat C-terminal ACTH
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
      Gene Symbol
      • POMC
      • pro-ACTH-endorphin
      • adrenocorticotropin
      • beta-LPH
      • POC
      • gamma-LPH
      • LPH
      • ACTH
      • corticotropin
      • beta-endorphin
      • beta-MSH
      • alpha-MSH
      • pro-opiomelanocortin
      • proopiomelanocortin
      • Pro-opiomelanocortin
      • corticotropin-lipotrophin
      • NPP
      • MSH
      • met-enkephalin
      • CLIP
      • gamma-MSH
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01189 # Beta-endorphin and Met-enkephalin are endogenous opiates.
      SIZE: 267 amino acids; 29424 Da
      TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland.
      PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. & O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
      DISEASE: SwissProt: P01189 # Defects in POMC may be associated with susceptibility to obesity [MIM:601665]. & Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.
      SIMILARITY: SwissProt: P01189 ## Belongs to the POMC family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size1 mg
      Global Trade Item Number
      产品目录编号 GTIN
      CBL56 04053252367243