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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

AB4235 Sigma-AldrichAnti-AMACR Antibody

Detect AMACR using this Anti-AMACR Antibody validated for use in WB, IH(P).

Anti-AMACR Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Apoptosis & Cancer Research Sub-Category: Tumor Markers Gene Symbol: AMACR, RACE, EC 5.1.99.4 UniProt Number: Q9UHK6

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IH(P)	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB4235
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-AMACR Antibody
Alternate Names	a-methylacyl-CoA racemase P504S
Background Information	Prostate-specific antigen (PSA) screening for prostate cancer is now widespread in the United States among men of all ages. However PSA has limited specificity because benign disease, including prostatic enlargement and inflammation, can increase PSA levels. Thus, a more specific prostate cancer markers is needed. One such potential marker is AMACR, an enzyme that is involved in peroxisomal beta-oxidation of dietary branched-chain fatty acids. Recent studies have shown that, compared with expression in normal or benign prostate epithelium, AMACR is consistently overexpressed in prostate cancer epithelium, making it a specific marker for cancer cells within the prostate gland. Furthermore, overexpression of AMACR may increase the risk of prostate cancer because its expression is increased in premalignant lesions (prostatic intraepithelial neoplasia).

References

Product Information
Format	Affinity Purified
Presentation	Peptide affinity purified antibody. Liquid in PBS, with 0.02% sodium azide as a preservative.
Quality Level	MQ300

Applications
Application	Detect AMACR using this Anti-AMACR Antibody validated for use in WB, IH(P).
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Western blot: 1:500 Immunohistochemistry: 1:100 in an ABC method. An incubation period of 30 minutes at room temperature is suggested. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	Synthetic human AMACR peptide.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes human AMACR (alpha-methylacyl-CoA racemase).
Species Reactivity	Human
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_014324.4 NM_203382.1
Entrez Gene Summary	Alpha-methylacyl-CoA racemase is responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers that can be degraded via peroxisomal beta-oxidation.[supplied by OMIM]
Gene Symbol	AMACR RACE EC 5.1.99.4
UniProt Number	Q9UHK6
UniProt Summary	FUNCTION: SwissProt: Q9UHK6 # Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. SIZE: 382 amino acids; 42360 Da SUBCELLULAR LOCATION: Peroxisome. Mitochondrion. DISEASE: SwissProt: Q9UHK6 # Defects in AMACR are the cause of AMACR deficiency [MIM:604489]. It results in elevated concentrations of pristanic acid. It is associated with a form of adult onset sensory motor neuropathy. & Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile. SIMILARITY: SwissProt: Q9UHK6 ## Belongs to the caiB/baiF CoA-transferase family.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at 2-8ºC in undiluted aliquots for 3 months or at -20°C for up to one year from date of receipt. Avoid repeated freeze-thaw cycles.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
AB4235	04053252508134

Documentation

Anti-AMACR Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-AMACR Antibody 分析证书

标题	批号
RABBIT ANTI-AMACR (P504S) POLYCLONAL ANTIBODY - 2368696	2368696
RABBIT ANTI-AMACR (P504S) - 3286444	3286444
RABBIT ANTI-AMACR (P504S) POLYCLONAL ANTIBODY	3063422
RABBIT ANTI-AMACR (P504S) POLYCLONAL ANTIBODY - 2361783	2361783
RABBIT ANTI-AMACR (P504S) POLYCLONAL ANTIBODY - 2365780	2365780

参考

参考概述	公共医疗ID
P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies. Beach, R, et al. Am. J. Surg. Pathol., 26: 1588-96 (2002) 2002	12459625

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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