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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

ABS571 Sigma-AldrichAnti-3-PGDH Antibody

This Anti-3-PGDH Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of 3-PGDH.

Anti-3-PGDH Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: PHGDH, PGDH3 UniProt Number: O43175

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, IH(P)	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABS571
Description	Anti-3-PGDH Antibody
Alternate Names	D-3-phosphoglycerate dehydrogenase 3-PGDH
Background Information	3-PGDH (PHGDH) protein in an important enzyme in L-serine biosynthesis. 3-PGDH performs the first rate limiting step in the phosphorylated pathway of serine biosynthesis. 3-PGDH is also a biomarker in certain cancers that over express 3-PGDH. Moreover, 3-PGDH is the essential enzyme needed for cells to traverse the S phase and divide, and it plays a key role in T cell activation and proliferation for instance. Interestingly, even though 3-PGDH knockdown and reduced serine synthesis slows growth and proliferation of many cancer cells in vitro 3-PGDH knockdown does not affect tumor maintenance and growth in established breast cancer xenograft models, suggesting that 3-PGDH-dependent cancer cell growth may be context-dependent.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-3-PGDH Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of 3-PGDH.
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected 3-PGDH in human cerebral cortex, human kidney, and human cerebellum tissue.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human 3-PGDH near the N-terminus.
Epitope	Near N-terminus
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Species Reactivity	Human Mouse
Species Reactivity Note	Human, Mouse. Predicted to react with Porcine, Chimpanzee based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_006614
Gene Symbol	PHGDH PGDH3
Purification Method	Affinity Purfied
UniProt Number	O43175
Molecular Weight	~54 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in A431 cell lysate. Western Blotting Analysis: 0.2 µg/mL of this antibody detected 3-PGDH in 10 µg of A431 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABS571	04055977073287

Documentation

Anti-3-PGDH Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-3-PGDH Antibody 分析证书

标题	批号
Anti-3-PGDH - Q2468767	Q2468767
Anti-3-PGDH - 3732255	3732255
Anti-3-PGDH - 3903329	3903329

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产品目录编号

描述

MABS1145

Anti-3-PGDH Antibody, clone TK-08 13A8

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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