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AB9744 Sigma-AldrichAnti-14-3-3 τ (tau) Antibody

Detect 14-3-3 τ (tau) using this Anti-14-3-3 τ (tau) Antibody validated for use in ELISA, WB, IH.

Anti-14-3-3 τ (tau) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: YWHAQ, HS1, 14-3-3, 1C5 UniProt Number: P27348

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概述

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
B, Ch, H, M, R, Rb, Sh	ELISA, WB, IHC	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	AB9744
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-14-3-3 τ (tau) Antibody
Background Information	Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's. The 14-3-3 tau antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.

References

Product Information
Format	Serum
Presentation	Liquid.
Quality Level	MQ100

Applications
Application	Detect 14-3-3 τ (tau) using this Anti-14-3-3 τ (tau) Antibody validated for use in ELISA, WB, IH.
Key Applications	ELISA Western Blotting Immunohistochemistry
Application Notes	Western blot: 1:3,000 using ECL. Immunohistochemistry: 1:30-1:60 on mouse brain tissue which was treated by hydrated autoclaving at 121°C for 15 minutes prior to immunolabeling. Endogenous peroxidase was blocked with hydrogen peroxide in methanol and non-specific labeling with normal goat serum at 1:20 for 5 minutes. ELISA Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	Synthetic peptide from the N-terminal area of sheep 14-3-3 tau.
Host	Rabbit
Specificity	14-3-3 tau (theta). By Western blot the antibody recognizes the ~30 kDa protein.
Species Reactivity	Bovine Chicken Human Mouse Rat Rabbit Sheep
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_006826.2
Entrez Gene Summary	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
Gene Symbol	YWHAQ HS1 14-3-3 1C5
Purification Method	Serum
UniProt Number	P27348
UniProt Summary	FUNCTION: SwissProt: P27348 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. SIZE: 245 amino acids; 27764 Da SUBUNIT: Interacts with PCTK1 (By similarity). Homodimer. Interacts with SSH1. SUBCELLULAR LOCATION: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals. TISSUE SPECIFICITY: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. SIMILARITY: SwissProt: P27348 ## Belongs to the 14-3-3 family.
Molecular Weight	30 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
AB9744	04053252509254

Documentation

Anti-14-3-3 τ (tau) Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-14-3-3 τ (tau) Antibody 分析证书

标题	批号
RABBIT ANTI-14-3-3 tau - 3277978	3277978
RABBIT ANTI-14-3-3 tau POLYCLONAL ANTIBODY	2476711

参考

参考概述	公共医疗ID
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1 Chen, Hung-Kai, et al Cell, 113:457-68 (2003) 2003	12757707
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain Baxter, H C, et al Neuroscience, 109:5-14 (2002) 2002	11784696
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation Wheeler-Jones, C P, et al Biochem J, 315 ( Pt 1):41-7 (1996) 1996	8670130

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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