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176905 Sigma-AldrichAnthrax Protective Antigen, Bacillus anthracis, Recombinant, B. anthracis - Calbiochem

Anthrax Protective Antigen, Bacillus anthracis, Recombinant, is the protective antigen that mediates the entry of anthrax lethal factor and edema factor into the target cell.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Recommended Products

概述

Replacement Information

价格及供货情况

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Description
Overview	Recombinant, Bacillus anthracis anthrax protective antigen expressed in a specialized strain of B. anthracis. One of the three protein components of Anthrax toxin, protective antigen (PA) is the central moiety that mediates the entry of lethal factor and edema factor into the target cell. PA binds to the cell surface via a type I membrane protein with a von Willebrand factor A domain called anthrax toxin receptor. After proteolytic activation to a 63 kDa fragment, PA self-associates to form a heptameric cation-selective, voltage-gated membrane channel.
Catalogue Number	176905
Brand Family	Calbiochem®

References
References	Mogridge, J., et al. 2002. Biochemistry 41, 1079. Nassi, S., et al. 2002. Biochemistry 41, 1445. Ahuja, N., et al. 2001. Biochem. Biophys. Res. Commun. 286, 6. Bradley, K.A., et al. 2001. Nature 414, 225. Brossier, F., and Mock, M. 2001. Toxicon 39, 1747.

Product Information
ATP Competitive	N
Form	Lyophilized
Formulation	Lyophilized from 50 mM NaCl, 5 mM HEPES, pH 7.5.
Reversible	N
Quality Level	MQ100

Applications
Application	Anthrax Protective Antigen, Bacillus anthracis, Recombinant, is the protective antigen that mediates the entry of anthrax lethal factor and edema factor into the target cell.

Biological Information
Primary Target	Type I membrane protein with a von Willebrand factor A domain called anthrax toxin receptor
Purity	Single major band by SDS-PAGE. Several smaller minor components are apparent that may represent cleavage fragments of the PA.

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 6 months at -20°C.
End use certificate	Y

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
176905-100UGCN	04055977223040

Documentation

Anthrax Protective Antigen, Bacillus anthracis, Recombinant, B. anthracis - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Anthrax Protective Antigen, Bacillus anthracis, Recombinant, B. anthracis - Calbiochem 分析证书

标题	批号
176905	输入批号

参考

参考信息概述
Mogridge, J., et al. 2002. Biochemistry 41, 1079. Nassi, S., et al. 2002. Biochemistry 41, 1445. Ahuja, N., et al. 2001. Biochem. Biophys. Res. Commun. 286, 6. Bradley, K.A., et al. 2001. Nature 414, 225. Brossier, F., and Mock, M. 2001. Toxicon 39, 1747.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-April-2008 RFH
Description	Recombinant, Bacillus anthracis anthrax protective antigen expressed in a special strain of B. anthracis. One of three protein components of anthrax toxin produced by the pathogenic bacterium, Bacillus anthracis. Central moiety that mediates entry of lethal factor (LF) and edema factor (EF) into the target cell. PA83 binds to the cell surface via a type I membrane receptor with a von Willebrand factor A domain, known as anthrax toxin receptor. PA83 is proteolytically activated in vivo by a furin-like protease to produce a 63 kDa protein (PA63). PA63 self-associates to form a heptameric, cation-selective, voltage-gated, membrane channel that subsequently binds to LF and/or EF. Cleavage of the 20 kDa fragment from PA83 is necessary for binding of protective antigen to LF and EF.
Form	Lyophilized
Formulation	Lyophilized from 50 mM NaCl, 5 mM HEPES, pH 7.5.
Purity	Single major band by SDS-PAGE. Several smaller minor components are apparent that may represent cleavage fragments of the PA.
Solubility	Reconstitute in 100 µl sterile, distilled H₂O to yield a final concentration of 1 mg/ml.
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Mogridge, J., et al. 2002. Biochemistry 41, 1079. Nassi, S., et al. 2002. Biochemistry 41, 1445. Ahuja, N., et al. 2001. Biochem. Biophys. Res. Commun. 286, 6. Bradley, K.A., et al. 2001. Nature 414, 225. Brossier, F., and Mock, M. 2001. Toxicon 39, 1747.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Anthrax Related Products

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