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172060 Sigma-AldrichAndrographolide - CAS 5508-58-7 - Calbiochem

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.

Andrographolide - CAS 5508-58-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Andro

Primary Target: NF-κB and AP-1 activation

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
5508-58-7	C₂₀H₃₀O₅

价格及供货情况

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Description
Overview	A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC₅₀ ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
Catalogue Number	172060
Brand Family	Calbiochem®
Synonyms	Andro

References
References	Xia, Y.F., et al. 2004. J. Immunol. 173, 4207. Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337. Yu, B.C., et al. 2003. Planta Med. 69, 1075.

Product Information
CAS number	5508-58-7
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₂₀H₃₀O₅
Chemical formula	C₂₀H₃₀O₅
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	NF-κB and AP-1 activation
Primary Target IC<sub>50</sub>	≤ 15 µM against NF-κB and AP-1 activation
Purity	≥95% by TLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	LU3490750

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
172060-50MGCN	04055977222883

Documentation

Andrographolide - CAS 5508-58-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Andrographolide - CAS 5508-58-7 - Calbiochem 分析证书

标题	批号
172060	输入批号

参考

参考信息概述
Xia, Y.F., et al. 2004. J. Immunol. 173, 4207. Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337. Yu, B.C., et al. 2003. Planta Med. 69, 1075.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-April-2008 RFH
Synonyms	Andro
Description	An irreversible blocker of NF-κB and AP-1 (IC₅₀ ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	5508-58-7
RTECS	LU3490750
Chemical formula	C₂₀H₃₀O₅
Structure formula
Purity	≥95% by TLC
Solubility	DMSO (15 mg/ml) or Chloroform:Methanol (1:1) (10 mg/ml). Use only fresh DMSO.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
Merck USA index	14, 633
References	Xia, Y.F., et al. 2004. J. Immunol. 173, 4207. Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337. Yu, B.C., et al. 2003. Planta Med. 69, 1075.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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