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A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
Catalogue Number
172060
Brand Family
Calbiochem®
Synonyms
Andro
References
References
Xia, Y.F., et al. 2004. J. Immunol.173, 4207. Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337. Yu, B.C., et al. 2003. Planta Med.69, 1075.
Xia, Y.F., et al. 2004. J. Immunol.173, 4207. Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337. Yu, B.C., et al. 2003. Planta Med.69, 1075.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
14-April-2008 RFH
Synonyms
Andro
Description
An irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
5508-58-7
RTECS
LU3490750
Chemical formula
C₂₀H₃₀O₅
Structure formula
Purity
≥95% by TLC
Solubility
DMSO (15 mg/ml) or Chloroform:Methanol (1:1) (10 mg/ml). Use only fresh DMSO.
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Carcinogenic / Teratogenic
Merck USA index
14, 633
References
Xia, Y.F., et al. 2004. J. Immunol.173, 4207. Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337. Yu, B.C., et al. 2003. Planta Med.69, 1075.
