数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

172050 Sigma-AldrichAnacardic Acid - CAS 16611-84-0 - Calbiochem

Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and inhibits protein SUMO modification (IC50 = 2.2 µM) in an ATP-dependent manner.

Anacardic Acid - CAS 16611-84-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: AA, 2-Hydroxy-6-pentadecylbenzoic Acid, 6-Pentadecylsalicylic Acid, Aurora Kinase A Activator, Histone Acetyltransferase Inhibitor III, SUMOylation Inhibitor II, HAT Inhibitor III, p300/CBP Inhibitor III, PCAF Inhibitor I

Primary Target: HAT

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
16611-84-0	C₂₂H₃₆O₃

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
172050-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable ginkgolic acid (Cat. No. 345887) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC₅₀ = 2.2 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation. Both anacardic acid and ginkgolic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although anacardic acid is shown to inhibit p300 (Cat. No. 506200) and PCAF (Cat. No. 124026) histone acetyltransferase activities in cell-free acetylase assays (by 82% and 86%, respectively, at 10 µM). Also reported to inhibit the activity of prostaglandin synthase, tyrosinase, and lipoxygenase, as well as to enhance Aurora kinase A (Cat. No. 481413), but not Aurora kinase B, autophosphorylation and kinase activity by inducing conformation change and enhancing ATP binding.
Catalogue Number	172050
Brand Family	Calbiochem®
Synonyms	AA, 2-Hydroxy-6-pentadecylbenzoic Acid, 6-Pentadecylsalicylic Acid, Aurora Kinase A Activator, Histone Acetyltransferase Inhibitor III, SUMOylation Inhibitor II, HAT Inhibitor III, p300/CBP Inhibitor III, PCAF Inhibitor I

References
References	Fukuda, I., et al. 2009. Chem. Biol. 16, 133. Kishore, A.H. 2008. J. Med. Chem. 51, 792. Balasubramanyam, K., et al. 2003. J. Biol. Chem. 278, 19134. Paramashivappa, R., et al. 2002. J. Agric. Food Chem. 50, 7709.

Product Information
CAS number	16611-84-0
ATP Competitive	Y
Declaration	Sold under license of U.S. Patent 7,332,629 and related patents.
Form	White solid
Hill Formula	C₂₂H₃₆O₃
Chemical formula	C₂₂H₃₆O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and inhibits protein SUMO modification (IC50 = 2.2 µM) in an ATP-dependent manner.

Biological Information
Primary Target	HAT
Primary Target IC<sub>50</sub>	5 µM against HAT; 8.5 µM against PCAF; 2.2 µM inhibiting protein SUMO modification using RanGAP1-C2 as substrate
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
172050-10MGCN	04055977222876

Documentation

Anacardic Acid - CAS 16611-84-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Anacardic Acid - CAS 16611-84-0 - Calbiochem 分析证书

标题	批号
172050	输入批号

参考

参考信息概述
Fukuda, I., et al. 2009. Chem. Biol. 16, 133. Kishore, A.H. 2008. J. Med. Chem. 51, 792. Balasubramanyam, K., et al. 2003. J. Biol. Chem. 278, 19134. Paramashivappa, R., et al. 2002. J. Agric. Food Chem. 50, 7709.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-May-2010 RFH
Synonyms	AA, 2-Hydroxy-6-pentadecylbenzoic Acid, 6-Pentadecylsalicylic Acid, Aurora Kinase A Activator, Histone Acetyltransferase Inhibitor III, SUMOylation Inhibitor II, HAT Inhibitor III, p300/CBP Inhibitor III, PCAF Inhibitor I
Description	A cell-permeable ginkgolic acid (Cat. No. 345887) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC₅₀ = 2.2 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation. Both anacardic acid and ginkgolic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although anacardic acid is shown to inhibit p300 (Cat. No. 506200) and PCAF (Cat. No. 124026) histone acetyltransferase activities in cell-free acetylase assays (by 82% and 86%, respectively, at 10 µM). Also reported to inhibit the activity of prostaglandin synthase, tyrosinase, and lipoxygenase, as well as to enhance Aurora kinase A (Cat. No. 481413), but not Aurora kinase B, autophosphorylation and kinase activity by inducing conformation change and enhancing ATP binding.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	16611-84-0
Chemical formula	C₂₂H₃₆O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml), Ethanol (10 mg/ml), or Methanol (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Fukuda, I., et al. 2009. Chem. Biol. 16, 133. Kishore, A.H. 2008. J. Med. Chem. 51, 792. Balasubramanyam, K., et al. 2003. J. Biol. Chem. 278, 19134. Paramashivappa, R., et al. 2002. J. Agric. Food Chem. 50, 7709.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

此产品已添加到您的购物车。