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126870 Sigma-AldrichAlsterpaullone - CAS 237430-03-4 - Calbiochem

A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC₅₀ = 4 nM) and Cdk1/cyclin B (IC₅₀ = 35 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
小册子
Data Sheet

同义词: 9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701

Primary Target: GSK-3β, Cdk1/cyclin B

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
237430-03-4	C₁₆H₁₁N₃O₃

价格及供货情况

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Description
Overview	A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC₅₀ = 4 nM) and Cdk1/cyclin B (IC₅₀ = 35 nM). Displays remarkable in vitro antitumor activity. Inhibits Tau phosphorylation at sites that are typically phosphorylated by GSK-3β in Alzheimer’s disease. Also inhibits Cdk5/p25-dependent phosphorylation of DARPP-32.
Catalogue Number	126870
Brand Family	Calbiochem®
Synonyms	9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701

References
References	Leost, M., et al. 2000. Eur. J. Biochem. 267, 5983. Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.

Product Information
CAS number	237430-03-4
ATP Competitive	Y
Form	Light yellow to brown solid
Hill Formula	C₁₆H₁₁N₃O₃
Chemical formula	C₁₆H₁₁N₃O₃
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	GSK-3β, Cdk1/cyclin B
Primary Target IC<sub>50</sub>	4 nM, 35 nM, against GSK-3β, Cdk1/cyclin B, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
126870-1MGCN	04055977222159

Documentation

Alsterpaullone - CAS 237430-03-4 - Calbiochem 分析证书

标题	批号
126870	输入批号

参考

参考信息概述
Leost, M., et al. 2000. Eur. J. Biochem. 267, 5983. Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.

小册子

标题
Alzheimer's Disease Brochure & Technical Guide

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-June-2019 JSW
Synonyms	9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
Description	A cell-permeable, potent, reversible, and ATP competitive inhibitor of cdk1/cyclin B (IC₅₀ = 35 nM) and GSK-3β (IC₅₀ = 4 nM). One of the most active paullones that acts by competing with ATP for binding to GSK-3β and inhibits the phosphorylation of tau. Also inhibits the activity of Cdk5/p25-dependent phosphorylation of DARPP-32 (a 32 kDa dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein). Displays remarkable antitumor activity in vitro. Inhibits growth of the colon cancer cell line HCT-116, with an IC₅₀ in the nanomolar range.
Form	Light yellow to brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	237430-03-4
Chemical formula	C₁₆H₁₁N₃O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Leost, M., et al. 2000. Eur. J. Biochem. 267, 5983. Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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