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124020 Sigma-AldrichAkt Inhibitor X - CAS 925681-41-0 - Calbiochem

Akt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
小册子
Data Sheet

同义词: 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-DEBC HC, 10-NCP

Primary Target: Akt

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
925681-41-0	C₂₀H₂₅ClN₂O • HCl

价格及供货情况

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Description
Overview	A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC₅₀ = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H₂O(Cat. No. 124039).
Catalogue Number	124020
Brand Family	Calbiochem®
Synonyms	10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-DEBC HC, 10-NCP

References
References	Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press. Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.

Product Information
CAS number	925681-41-0
ATP Competitive	N
Form	White solid
Hill Formula	C₂₀H₂₅ClN₂O • HCl
Chemical formula	C₂₀H₂₅ClN₂O • HCl
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Akt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.

Biological Information
Primary Target	Akt
Primary Target IC<sub>50</sub>	<5 µM against Akt ; 2-5 µM against growth of Rh (rhabdomyosarcoma) cell lines
Secondary target	Rn cell lines (IC₅₀ = 2-5 µM)
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
124020-5MGCN	04055977205749

Documentation

Akt Inhibitor X - CAS 925681-41-0 - Calbiochem 分析证书

标题	批号
124020	输入批号

参考

参考信息概述
Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press. Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.

小册子

标题
Akt

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-September-2010 JSW
Synonyms	10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-DEBC HC, 10-NCP
Description	A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC₅₀ = 2-5 μM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	925681-41-0
Chemical formula	C₂₀H₂₅ClN₂O • HCl
Structure formula
Purity	≥95% by HPLC
Solubility	H₂O (1 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press. Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Akt (Protein Kinase B) Inhibitors

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