数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

124012 Sigma-AldrichAkt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
35943-35-2	C₁₃H₁₆N₆O₄

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
124012-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
124012-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038).
Catalogue Number	124012
Brand Family	Calbiochem®
Synonyms	NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2

References
References	Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394.

Product Information
CAS number	35943-35-2
ATP Competitive	N
Form	Solid
Hill Formula	C₁₃H₁₆N₆O₄
Chemical formula	C₁₃H₁₆N₆O₄
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.

Biological Information
Primary Target	Akt1, Akt 2, Akt3
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	RY8455000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
124012-10MGCN	04055977205640
124012-1MGCN	04055977205633

Documentation

Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem 分析证书

标题	批号
124012	输入批号

参考

参考信息概述
Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394.

小册子

标题
Akt
Biologics 31.1

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-January-2012 RFH
Synonyms	NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
Description	A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038.
Form	Solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	35943-35-2
RTECS	RY8455000
Chemical formula	C₁₃H₁₆N₆O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml). Further dilute at aqueous buffer in low micromolar concentrations.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Akt (Protein Kinase B) Inhibitors

此产品已添加到您的购物车。