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123871 Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem

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产品目录编号 库存情况包装 数量 / 包装 价格 数量
123871-25MGCN
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      玻璃瓶 25 mg
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      Description
      OverviewA cell-permeable and blood-brain barrier permeant HA14-1 (Cat. No. 371971) analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO model (40 mg/kg, i.p.) in vivo.
      Catalogue Number123871
      Brand Family Calbiochem®
      SynonymsEthyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
      References
      ReferencesJo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.
      Product Information
      CAS number305834-79-1
      FormOff-white solid
      Hill FormulaC₁₇H₁₇ClN₂O₅
      Chemical formulaC₁₇H₁₇ClN₂O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetPleckstrin homology (PH) domain of Akt
      Purity≥98% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and immediately freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      产品目录编号 GTIN
      123871-25MGCN 04055977206319