123871 Sigma-AldrichAkt Activator II, SC79 - CAS 305834-79-1 - Calbiochem
Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more susceptible to phosphorylation by upstream Kinases.
More>> Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more susceptible to phosphorylation by upstream Kinases. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
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概述
价格及供货情况
产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
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123871-25MGCN |
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玻璃瓶 | 25 mg |
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Description | |
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Overview | A cell-permeable and blood-brain barrier permeant HA14-1 (Cat. No. 371971) analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO model (40 mg/kg, i.p.) in vivo. |
Catalogue Number | 123871 |
Brand Family | Calbiochem® |
Synonyms | Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
References | |
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References | Jo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581. |
Product Information | |
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CAS number | 305834-79-1 |
Form | Off-white solid |
Hill Formula | C₁₇H₁₇ClN₂O₅ |
Chemical formula | C₁₇H₁₇ClN₂O₅ |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | Pleckstrin homology (PH) domain of Akt |
Purity | ≥98% by HPLC (sum of two isomers) |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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产品目录编号 | GTIN |
123871-25MGCN | 04055977206319 |