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182690 Sigma-AldrichAhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem

The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine

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概述

Replacement Information

价格及供货情况

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Description
Overview	A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC₅₀ of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
Catalogue Number	182690
Brand Family	Calbiochem®
Synonyms	(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine

References
References	Platzer, B., et al. 2009. J. Immunol. 183, 66. Hauben, E., et al. 2008. Blood 118, 1214. Lawrence, B.P., et al. 2008. Blood 112, 1158. Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.

Product Information
CAS number	574759-62-9
Form	White solid
Hill Formula	C₁₇H₁₁ClF₃N₃
Chemical formula	C₁₇H₁₁ClF₃N₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
182690-10MGCN	04055977204445

Documentation

AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem 分析证书

标题	批号
182690	输入批号

参考

参考信息概述
Platzer, B., et al. 2009. J. Immunol. 183, 66. Hauben, E., et al. 2008. Blood 118, 1214. Lawrence, B.P., et al. 2008. Blood 112, 1158. Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-August-2012 JSW
Synonyms	(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
Description	A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC₅₀ of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	574759-62-9
Chemical formula	C₁₇H₁₁ClF₃N₃
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Platzer, B., et al. 2009. J. Immunol. 183, 66. Hauben, E., et al. 2008. Blood 118, 1214. Lawrence, B.P., et al. 2008. Blood 112, 1158. Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.

种类

Life Science Research > Inhibitors and Biochemicals

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