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A cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
Catalogue Number
116860
Brand Family
Calbiochem®
Synonyms
2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
References
References
Robak, T. 2007. Cancer Treat. Rev.33, 710. Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev.44, 459. Agarwal, R.P., et al. 1977. Biochem. Pharmacol.26, 359.
Possible risk of impaired fertility. Possible risk of harm to the unborn child.
S Phrase
S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Harmful & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
116860-10MGCN
04055977223934
Documentation
Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem MSDS
Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem 分析证书
标题
批号
116860
参考
参考信息概述
Robak, T. 2007. Cancer Treat. Rev.33, 710. Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev.44, 459. Agarwal, R.P., et al. 1977. Biochem. Pharmacol.26, 359.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
18-May-2012 JSW
Synonyms
2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
Description
A cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
