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An adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
Catalogue Number
119139
Brand Family
Calbiochem®
Synonyms
2-Cl-IB-MECA, 2-chloro-IB-MECA
References
References
Kim, H. O., et al. 1994. J Med Chem.37, 3614. Laudadio, M. A., et al. 2004. Epilepsy Res.59, 83. Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther.319, 1200.
Kim, H. O., et al. 1994. J Med Chem.37, 3614. Laudadio, M. A., et al. 2004. Epilepsy Res.59, 83. Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther.319, 1200.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
28-April-2014 JSW
Synonyms
2-Cl-IB-MECA, 2-chloro-IB-MECA
Description
An adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
163042-96-4
Chemical formula
C₁₈H₁₈ClIN₆O₄
Purity
≥98% by HPLC
Solubility
DMSO (20 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Kim, H. O., et al. 1994. J Med Chem.37, 3614. Laudadio, M. A., et al. 2004. Epilepsy Res.59, 83. Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther.319, 1200.
