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114825 Adapalene - CAS 106685-40-9 - Calbiochem

A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.

Adapalene - CAS 106685-40-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271

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114825
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
106685-40-9C₂₈H₂₈O₃

价格及供货情况

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114825-25MGCN
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      Description
      OverviewA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
      Catalogue Number114825
      Brand Family Calbiochem®
      SynonymsCD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
      References
      ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
      Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
      Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
      Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.
      Product Information
      CAS number106685-40-9
      FormWhite solid
      Hill FormulaC₂₈H₂₈O₃
      Chemical formulaC₂₈H₂₈O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      114825-25MGCN 04055977208122

      Documentation

      Adapalene - CAS 106685-40-9 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Adapalene - CAS 106685-40-9 - Calbiochem 分析证书

      标题批号
      114825

      参考

      参考信息概述
      Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
      Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
      Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
      Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.

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      技术信息

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      用户指南

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      Analytical Procedures and Appendices Spectroquant Prove 300
      Analytical Procedures and Appendices Spectroquant®Prove 600
      Manual Spectroquant Multy - Operating manual
      Manual Spectroquant®Prove Connect to Dashboard - English
      Manual Spectroquant®Prove Connect to LIMS - English
      Quick Guide Spectroquant Photometer NOVA 60A (EN, DE, FR, ES, IT)
      User Guide (IFU) - 1.14825
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-September-2010 RFH
      SynonymsCD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
      DescriptionA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number106685-40-9
      Chemical formulaC₂₈H₂₈O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (12 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
      Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
      Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
      Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.

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      种类

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Vitamins, Coenzymes and Cofactors