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114802 Sigma-AldrichAdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem

A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.

AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
小册子
Data Sheet

同义词: Adamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI

Primary Target: chymotrypsin-like activity of the 20S proteasome

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
389064-25-9	C₅₀H₈₈N₆O₈S

价格及供货情况

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Description
Overview	A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.
Catalogue Number	114802
Brand Family	Calbiochem®
Synonyms	Adamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI

References
References	Kessler, B.M., et al. 2001. Chem. Biol. 8, 913.

Product Information
CAS number	389064-25-9
ATP Competitive	N
Form	Off-white powder
Hill Formula	C₅₀H₈₈N₆O₈S
Chemical formula	C₅₀H₈₈N₆O₈S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	chymotrypsin-like activity of the 20S proteasome
Primary Target IC<sub>50</sub>	50-100 nM against chymotrypsin-like activity of the 20S proteasome
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
114802-250UGCN	04055977208108

Documentation

AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem 分析证书

标题	批号
114802	输入批号

参考

参考信息概述
Kessler, B.M., et al. 2001. Chem. Biol. 8, 913.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-October-2007 RFH
Synonyms	Adamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI
Description	A cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 µM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 µM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 µM).
Form	Off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	389064-25-9
Chemical formula	C₅₀H₈₈N₆O₈S
Structure formula
Purity	≥90% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Kessler, B.M., et al. 2001. Chem. Biol. 8, 913.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors

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