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190080 Sigma-AldrichAY 9944 - CAS 366-93-8 - Calbiochem

A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification.

AY 9944 - CAS 366-93-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV

Primary Target: 7-dehydrocholesterol reductase (δ7-sterol reductase)

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
366-93-8	C₂₂H₂₈Cl₂N₂ • 2HCl

价格及供货情况

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Description
Overview	A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ⁷-sterol reductase) activity with IC₅₀= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
Catalogue Number	190080
Brand Family	Calbiochem®
Synonyms	trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV

References
References	Gofflot, F., et al. 2001. Dev. Dyn. 220, 99. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553. Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899. Yoshida, Y. 1985. J. Biochem. 98, 1669. Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.

Product Information
CAS number	366-93-8
ATP Competitive	N
Form	White solid
Hill Formula	C₂₂H₂₈Cl₂N₂ • 2HCl
Chemical formula	C₂₂H₂₈Cl₂N₂ • 2HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	7-dehydrocholesterol reductase (δ7-sterol reductase)
Primary Target IC<sub>50</sub>	13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	GU7025000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
190080-5MGCN	04055977221336

Documentation

AY 9944 - CAS 366-93-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

AY 9944 - CAS 366-93-8 - Calbiochem 分析证书

标题	批号
190080	输入批号

参考

参考信息概述
Gofflot, F., et al. 2001. Dev. Dyn. 220, 99. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553. Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899. Yoshida, Y. 1985. J. Biochem. 98, 1669. Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-October-2007 JSW
Synonyms	trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
Description	A cell-permeable, amphiphilic diamine that acts as a potent inhibitor of cholesterol biosynthesis and esterification and exhibits teratogenic properties. Specifically blocks 7-dehydro-cholesterol reductase (Δ⁷-sterol reductase; DHC) activity with IC₅₀= 13 nM. Reported to disrupt Sonic Hedgehog (Shh) signaling during embryogenesis in rats. Also reported to induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	366-93-8
RTECS	GU7025000
Chemical formula	C₂₂H₂₈Cl₂N₂ • 2HCl
Structure formula
Purity	≥95% by HPLC
Solubility	H₂O (20 mg/ml) or DMSO (20 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful & Carcinogenic / Teratogenic
References	Gofflot, F., et al. 2001. Dev. Dyn. 220, 99. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553. Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899. Yoshida, Y. 1985. J. Biochem. 98, 1669. Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Sonic Hedgehog Signaling Inhibitors

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