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189299 Sigma-AldrichATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem

The ATR/CDK Inhibitor, NU6027, also referenced under CAS 220036-08-8, controls the biological activity of ATR/CDK. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: ATR Inhibitor, NU6027, 2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, CDK2 Inhibitor, NU6027

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
220036-08-8	C₁₁H₁₇N₅O₂

价格及供货情况

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Description
Overview	A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (K_i = 2.5 µM for CDK1, and K_i = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC₅₀ = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells.
Catalogue Number	189299
Brand Family	Calbiochem®
Synonyms	ATR Inhibitor, NU6027, 2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, CDK2 Inhibitor, NU6027

References
References	Peasland, A., et al. 2011., Br J Cancer. 105, 372. Arris, C.E, et al. 2000., J Med Chem. 43, 2797.

Product Information
CAS number	220036-08-8
Form	Reddish-purple powder
Hill Formula	C₁₁H₁₇N₅O₂
Chemical formula	C₁₁H₁₇N₅O₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
189299-10MGCN	04055977221718

Documentation

ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem 分析证书

标题	批号
189299	输入批号

参考

参考信息概述
Peasland, A., et al. 2011., Br J Cancer. 105, 372. Arris, C.E, et al. 2000., J Med Chem. 43, 2797.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	25-May-2012 JSW
Synonyms	ATR Inhibitor, NU6027, 2,6-diamino-4-cyclohexyl-methyloxy-5-nitroso-pyrimidine, CDK2 Inhibitor, NU6027
Description	A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (K_i = 2.5 µM for CDK1, and K_i = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC₅₀ = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells.
Form	Reddish-purple powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	220036-08-8
Chemical formula	C₁₁H₁₇N₅O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml; clear, blue solution)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Peasland, A., et al. 2011., Br J Cancer. 105, 372. Arris, C.E, et al. 2000., J Med Chem. 43, 2797.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Checkpoint Kinase Inhibitors

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