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171272 Sigma-AldrichAMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem

The AMPK Activator VI, RSVA314 modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: RSVA314, AMPK Signaling Activator VI

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
316130-82-2	C₁₈H₂₁N₃O₃

价格及供货情况

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Description
Overview	A cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC₅₀ of 1-2 µM. Treatment with RSVA314 at 1-3 µM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots.
Catalogue Number	171272
Brand Family	Calbiochem®
Synonyms	RSVA314, AMPK Signaling Activator VI

References
References	Vingtdeux, V., et al. 2011. FASEB J. 25, 219.

Product Information
CAS number	316130-82-2
Form	Yellow solid
Hill Formula	C₁₈H₂₁N₃O₃
Chemical formula	C₁₈H₂₁N₃O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	>90% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
171272-10MGCN	04055977207217

Documentation

AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem 分析证书

标题	批号
171272	输入批号

参考

参考信息概述
Vingtdeux, V., et al. 2011. FASEB J. 25, 219.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-October-2011 RFH
Synonyms	RSVA314, AMPK Signaling Activator VI
Description	A cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC₅₀ of 1-2 µM. Treatment with RSVA314 at 1-3 µM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	316130-82-2
Chemical formula	C₁₈H₂₁N₃O₃
Structure formula
Purity	>90% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Vingtdeux, V., et al. 2011. FASEB J. 25, 219.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators > AMP-Activated Protein Kinase Activators

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