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171256 AMPK Activator - CAS 849727-81-7 - Calbiochem

The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I

Primary Target: AMPK
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171256
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
849727-81-7C₂₂H₂₁FO₄

价格及供货情况

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      		 玻璃瓶 5 mg
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      Description
      OverviewA cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
      Catalogue Number171256
      Brand Family Calbiochem®
      Synonyms5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
      References
      ReferencesKosaka, T., et al. 2005. Anal. Chem. 77, 2050.
      Product Information
      CAS number849727-81-7
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₂₂H₂₁FO₄
      Chemical formulaC₂₂H₂₁FO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAMPK
      Primary Target IC<sub>50</sub>EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      171256-5MGCN 04055977207118

      Documentation

      AMPK Activator - CAS 849727-81-7 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      AMPK Activator - CAS 849727-81-7 - Calbiochem 分析证书

      标题批号
      171256

      参考

      参考信息概述
      Kosaka, T., et al. 2005. Anal. Chem. 77, 2050.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-April-2008 RFH
      Synonyms5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
      DescriptionA cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number849727-81-7
      Chemical formulaC₂₂H₂₁FO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesKosaka, T., et al. 2005. Anal. Chem. 77, 2050.