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123850 Sigma-AldrichAKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem

The AKR1C1 Inhibitor, 5-PBSA, also referenced under CAS 4906-68-7, controls the biological activity of AKR1C1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
4906-68-7	C₁₃H₉BrO₃

价格及供货情况

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Description
Overview	A cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (K_i = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (K_i = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC₅₀ = 460 nM in AKR1C1 overexpressing BAECs).
Catalogue Number	123850
Brand Family	Calbiochem®
Synonyms	Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA

References
References	El-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105. El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.

Product Information
CAS number	4906-68-7
Form	White solid
Hill Formula	C₁₃H₉BrO₃
Chemical formula	C₁₃H₉BrO₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥94% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
123850-25MGCN	04055977206296

Documentation

AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem 分析证书

标题	批号
123850	输入批号

参考

参考信息概述
El-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105. El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-July2-2012 JSW
Synonyms	Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
Description	A cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (K_i = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (K_i = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC₅₀ = 460 nM in AKR1C1 overexpressing BAECs).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	4906-68-7
Chemical formula	C₁₃H₉BrO₃
Structure formula
Purity	≥94% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	El-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105. El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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