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123040 Sigma-AldrichAICA-Riboside - CAS 2627-69-2 - Calbiochem

AICA-Riboside, CAS 2627-69-2, is a cell-permeable nucleoside compound whose phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis.

AICA-Riboside - CAS 2627-69-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: Acadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II

Primary Target: Adenosine monophosphate-activated protein kinase (AMPK)

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
2627-69-2	C₉H₁₄N₄O₅

价格及供货情况

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Description
Overview	A cell-permeable nucleoside compound whose phosphorylated metabolite activates adenosine monophosphate-activated protein kinase (AMPK) and acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in perfused and isolated muscle. Offers protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and Aβ peptide.
Catalogue Number	123040
Brand Family	Calbiochem®
Synonyms	Acadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II

References
References	Meli, M., et al. 2006. J. Med. Chem. in press. Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45. Muoio, D.M., et al. 1999. Biochem. J. 338, 783. Hayashi, T., et al. 1998. Diabetes 47, 1369. Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.

Product Information
CAS number	2627-69-2
ATP Competitive	N
Form	White to brown solid
Hill Formula	C₉H₁₄N₄O₅
Chemical formula	C₉H₁₄N₄O₅
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Adenosine monophosphate-activated protein kinase (AMPK)
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
123040-50MGCN	04055977206272

Documentation

AICA-Riboside - CAS 2627-69-2 - Calbiochem 分析证书

标题	批号
123040	输入批号

参考

参考信息概述
Meli, M., et al. 2006. J. Med. Chem. in press. Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45. Muoio, D.M., et al. 1999. Biochem. J. 338, 783. Hayashi, T., et al. 1998. Diabetes 47, 1369. Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	09-June-2023 JSW
Synonyms	Acadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
Description	A cell-permeable nucleoside compound that is processed intracellularly to form a phosphorylated metabolite, which activates adenosine monophosphate-activated protein kinase (AMPK) without disrupting the cellular concentrations of ATP, ADP, or AMP. Also acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in both perfused and isolated muscle. AICAr-stimulated glucose transport is not affected by Wortmannin (Cat. No. 681675), a PI-3K inhibitor. Shown to inhibit the synthesis of triacylglycerol (TAG), diacylglycerol (DAG), and phospholipid, probably as a result of AMPK activation and the subsequent inhibition of sn-glycerol-3-phosphate acyltransferase (GPAT) by AMPK. Also reported to inhibit Hsp90 chaperone function. Imparts protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and amyloid β (Aβ) peptide.
Form	White to brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	2627-69-2
Chemical formula	C₉H₁₄N₄O₅
Structure formula
Purity	≥98% by HPLC
Solubility	Methanol (10 mg/ml) or H₂O. May require heating to 50°C to achieve complete solubilization in methanol.
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Meli, M., et al. 2006. J. Med. Chem. in press. Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45. Muoio, D.M., et al. 1999. Biochem. J. 338, 783. Hayashi, T., et al. 1998. Diabetes 47, 1369. Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators > AMP-Activated Protein Kinase Activators

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