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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

121765 Sigma-AldrichAG 825 - CAS 149092-50-2 - Calbiochem

A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC₅₀ = 0.35 µM) relative to HER1 (IC₅₀= 19 µM) autophosphorylation.

AG 825 - CAS 149092-50-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide

Primary Target: HER2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
149092-50-2	C₁₉H₁₅N₃O₃S₂

价格及供货情况

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Description
Overview	A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC₅₀ = 0.35 µM) relative to HER1 (IC₅₀= 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185^neu.
Catalogue Number	121765
Brand Family	Calbiochem®
Synonyms	4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide

References
References	Ashton, J.M., et al. 2012. Cell Stem Cell 11, 359. Tsai, C.M., et al. 1996. Cancer Res. 56, 1068. Levitzki, A., and Gazit, A. 1995. Science 267, 1782. Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.

Product Information
CAS number	149092-50-2
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₉H₁₅N₃O₃S₂
Chemical formula	C₁₉H₁₅N₃O₃S₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	HER2
Primary Target IC<sub>50</sub>	0.35 µM against HER2
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
121765-2MGCN	07790788047917

Documentation

AG 825 - CAS 149092-50-2 - Calbiochem 分析证书

标题	批号
121765	输入批号

参考

参考信息概述
Ashton, J.M., et al. 2012. Cell Stem Cell 11, 359. Tsai, C.M., et al. 1996. Cancer Res. 56, 1068. Levitzki, A., and Gazit, A. 1995. Science 267, 1782. Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-March-2015 JSW
Synonyms	4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
Description	A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC₅₀ = 0.35 µM) relative to HER-1 (IC₅₀ = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185^neu.
Form	Yellow solid
CAS number	149092-50-2
Chemical formula	C₁₉H₁₅N₃O₃S₂
Structure formula
Purity	≥94% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
Toxicity	Standard Handling
References	Ashton, J.M., et al. 2012. Cell Stem Cell 11, 359. Tsai, C.M., et al. 1996. Cancer Res. 56, 1068. Levitzki, A., and Gazit, A. 1995. Science 267, 1782. Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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