658401 Sigma-AldrichAG 490 - CAS 133550-30-8 - Calbiochem
A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM).
More>> A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM). Less<<AG 490 - CAS 133550-30-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 133550-30-8 | C₁₇H₁₄N₂O₃ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
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| 658401-5MGCN |
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塑胶安瓿;塑胶针药瓶 | 5 mg |
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| Description | |
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| Overview | A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Inhibition of JAK2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658411) in DMSO is also available. |
| Catalogue Number | 658401 |
| Brand Family | Calbiochem® |
| Synonyms | α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI |
| Product Information | |
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| CAS number | 133550-30-8 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₇H₁₄N₂O₃ |
| Chemical formula | C₁₇H₁₄N₂O₃ |
| Reversible | Y |
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| Quality Level | MQ100 |
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| Cell permeable | Y |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 658401-5MGCN | 07790788052218 |
Documentation
AG 490 - CAS 133550-30-8 - Calbiochem MSDS
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AG 490 - CAS 133550-30-8 - Calbiochem 分析证书
| 标题 | 批号 |
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| 658401 |
参考
| 参考信息概述 |
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| Jaleel, M., et al. 2004. Biochemistry 43, 8247. Eriksen, K.W., et al. 2001. Leukemia 15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913. |
小册子
| 标题 |
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| An Introduction to Inhibitors and Their Biological Applications - 1st Edition |
| Caspases and other Apoptosis Related Tools Brochure |
海报
| 标题 |
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| Human Kinome & InhibitorSelect™ Libraries |
引用
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