数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

658395 Sigma-AldrichAG 18 - CAS 118409-57-7 - Calbiochem

A broad-spectrum protein tyrosine kinase inhibitor.

AG 18 - CAS 118409-57-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810

Primary Target: epidermal growth factor receptor autophosphorylation

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
118409-57-7	C₁₀H₆N₂O₂

价格及供货情况

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Description
Overview	A broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC₅₀ = 40 µM) and the GTPase activity of transducin (IC₅₀ = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
Catalogue Number	658395
Brand Family	Calbiochem®
Synonyms	α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810

References
References	Jaleel, M., et al. 2004. Biochemistry 43, 8247. Kapas, S., et al. 1995. Biochem. J. 305, 433. Seger, R., et al. 1995. J. Biol. Chem. 270, 28325. Williams, J.A. 1994. Am. J. Physiol. 267, G401. Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344. Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.

References

Jaleel, M., et al. 2004. Biochemistry 43, 8247.
Kapas, S., et al. 1995. Biochem. J. 305, 433.
Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
Williams, J.A. 1994. Am. J. Physiol. 267, G401.
Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.

Product Information
CAS number	118409-57-7
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₀H₆N₂O₂
Chemical formula	C₁₀H₆N₂O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	epidermal growth factor receptor autophosphorylation
Primary Target IC<sub>50</sub>	40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
658395-5MGCN	04055977261547

Documentation

AG 18 - CAS 118409-57-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

AG 18 - CAS 118409-57-7 - Calbiochem 分析证书

标题	批号
658395	输入批号

参考

参考信息概述
Jaleel, M., et al. 2004. Biochemistry 43, 8247. Kapas, S., et al. 1995. Biochem. J. 305, 433. Seger, R., et al. 1995. J. Biol. Chem. 270, 28325. Williams, J.A. 1994. Am. J. Physiol. 267, G401. Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344. Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-May-2011 RFH
Synonyms	α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
Description	A cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC₅₀ = 40 µM) and the GTPase activity of transducin (IC₅₀ = 10 µM). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.
Form	Yellow solid
CAS number	118409-57-7
Chemical formula	C₁₀H₆N₂O₂
Structure formula
Purity	≥98% by HPLC
Solubility	Acetic acid, DMSO (100 mg/ml), or ethanol (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
References	Jaleel, M., et al. 2004. Biochemistry 43, 8247. Kapas, S., et al. 1995. Biochem. J. 305, 433. Seger, R., et al. 1995. J. Biol. Chem. 270, 28325. Williams, J.A. 1994. Am. J. Physiol. 267, G401. Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344. Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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