Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
658425
Sigma-AldrichAG 17 - CAS 10537-47-0 - Calbiochem
Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM).
More>>Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). Less<<
AG 17 - CAS 10537-47-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). A potent, cell-permeable, reversible, and substrate competitive inhibitor of TNF-induced tyrosine phosphorylation of PYK2. Uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in NHL cell lines. Inhibits Cdk2 activity in lymphoma cell lines.
Fuortes, M., et al. 1999. J. Clin. Invest.104, 327. Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434. Burger, A.M., et al. 1995. Cancer Res.55, 2794. Palumbo, G.A., et al. 1994. Blood84, 296a. Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721. Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171. Terada, H. 1981. Biochim. Biophys. Acta639, 225
500 nM against platelet-derived growth factor receptor tyrosine kinase
Purity
≥99% by TLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
OO3737000
Safety Information
R Phrase
R: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S Phrase
S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Fuortes, M., et al. 1999. J. Clin. Invest.104, 327. Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434. Burger, A.M., et al. 1995. Cancer Res.55, 2794. Palumbo, G.A., et al. 1994. Blood84, 296a. Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721. Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171. Terada, H. 1981. Biochim. Biophys. Acta639, 225
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.
Form
Pale yellow solid
CAS number
10537-47-0
RTECS
OO3737000
Chemical formula
C₁₈H₂₂N₂O
Structure formula
Purity
≥99% by TLC
Solubility
DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity
Toxic
References
Fuortes, M., et al. 1999. J. Clin. Invest.104, 327. Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434. Burger, A.M., et al. 1995. Cancer Res.55, 2794. Palumbo, G.A., et al. 1994. Blood84, 296a. Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721. Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171. Terada, H. 1981. Biochim. Biophys. Acta639, 225
