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A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.
Catalogue Number
104550
Brand Family
Calbiochem®
Synonyms
N-(p-Amylcinnamoyl)anthranilic Acid
References
References
Liu, L., et al. 1999. J. Cell. Biochem.72, 103. Simonsson, E., et al. 1998. Diabetes47, 1436. Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215. Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
104550-25MGCN
04055977226461
Documentation
ACA - CAS 110683-10-8 - Calbiochem 分析证书
标题
批号
104550
参考
参考信息概述
Liu, L., et al. 1999. J. Cell. Biochem.72, 103. Simonsson, E., et al. 1998. Diabetes47, 1436. Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215. Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
30-August-2016 JSW
Synonyms
N-(p-Amylcinnamoyl)anthranilic Acid
Description
Inhibits epinephrine-stimulated thromboxane production (86% at 3.5 μM) via inhibition of phospholipase A2 (PLA2) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.
Form
White solid
CAS number
110683-10-8
Chemical formula
C₂₁H₂₃NO₃
Structure formula
Purity
≥99% by HPLC
Solubility
Ethanol (10 mg/ml) or DMSO (50 mg/ml)
Storage
Protect from light
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Liu, L., et al. 1999. J. Cell. Biochem.72, 103. Simonsson, E., et al. 1998. Diabetes47, 1436. Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215. Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.
