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390900 Sigma-Aldrich4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem

A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: Fenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide

Primary Target: Active in the prevention and treatment of a variety of neoplasms in animals.

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
65646-68-6	C₂₆H₃₃NO₂

价格及供货情况

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Description
Overview	A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits human breast cancer, prostate adenocarcinoma, and ovarian carcinoma cell proliferation. Inhibits angiogenesis as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
Catalogue Number	390900
Brand Family	Calbiochem®
Synonyms	Fenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide

References
References	Formelli, F., et al. 1996. FASEB J. 10, 1014. Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315. Delia, D., et al. 1993. Cancer Res. 53, 6036. Pienta, K.J., et al. 1993. Cancer Res. 53, 224. Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661. McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014. Moon, R.C., et al. 1979. Cancer Res. 39, 1339.

Product Information
CAS number	65646-68-6
ATP Competitive	N
Form	Orange solid
Hill Formula	C₂₆H₃₃NO₂
Chemical formula	C₂₆H₃₃NO₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Active in the prevention and treatment of a variety of neoplasms in animals.
Purity	≥97% by TLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	VH6420000

Safety Information
R Phrase	R: 20/21/22-36/37/38-60-61 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. May impair fertility. May cause harm to the unborn child.
S Phrase	S: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
390900-5MGCN	04055977190007

Documentation

4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem 分析证书

标题	批号
390900	输入批号

参考

参考信息概述
Formelli, F., et al. 1996. FASEB J. 10, 1014. Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315. Delia, D., et al. 1993. Cancer Res. 53, 6036. Pienta, K.J., et al. 1993. Cancer Res. 53, 224. Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661. McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014. Moon, R.C., et al. 1979. Cancer Res. 39, 1339.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-March-2008 JSW
Synonyms	Fenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide
Description	A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits proliferation in cell lines of human breast cancer, prostate adenocarcinoma, and ovarian carcinoma. Inhibits angiogenesis, as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
Form	Orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	65646-68-6
RTECS	VH6420000
Chemical formula	C₂₆H₃₃NO₂
Structure formula
Purity	≥97% by TLC
Solubility	Acetone, DMSO (25 mg/ml), or Ethanol
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful & Carcinogenic / Teratogenic
Merck USA index	14, 3998
References	Formelli, F., et al. 1996. FASEB J. 10, 1014. Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315. Delia, D., et al. 1993. Cancer Res. 53, 6036. Pienta, K.J., et al. 1993. Cancer Res. 53, 224. Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661. McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014. Moon, R.C., et al. 1979. Cancer Res. 39, 1339.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

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