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287815 Sigma-Aldrich3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
51050-59-0	C₉H₄Cl₂O₂

价格及供货情况

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Description
Overview	A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.
Overview	Effective concentration: 5-100 µM; t_½ = 20 min at pH 7.5.
Catalogue Number	287815
Brand Family	Calbiochem®

References
References	Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631. Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488. Odake, S., et al. 1991. Biochemistry 30, 2217. Harper, J.W., et al. 1985. Biochemistry 24, 1831.

Product Information
CAS number	51050-59-0
ATP Competitive	N
Form	White lyophilized solid
Hill Formula	C₉H₄Cl₂O₂
Chemical formula	C₉H₄Cl₂O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	serine proteases
Primary Target IC<sub>50</sub>	5-100 µM
Purity	≥99% by elemental analysis

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
287815-10MGCN	04055977197860

Documentation

3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem 分析证书

标题	批号
287815	输入批号

参考

参考信息概述
Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631. Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488. Odake, S., et al. 1991. Biochemistry 30, 2217. Harper, J.W., et al. 1985. Biochemistry 24, 1831.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-June-2008 RFH
Description	A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 µM.
Form	White lyophilized solid
CAS number	51050-59-0
Chemical formula	C₉H₄Cl₂O₂
Structure formula
Purity	≥99% by elemental analysis
Solubility	DMF (10 mM) or DMSO (10 mM)
Storage	Protect from moisture +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631. Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488. Odake, S., et al. 1991. Biochemistry 30, 2217. Harper, J.W., et al. 1985. Biochemistry 24, 1831.
Citation	Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingomyelinase Kinase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

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