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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

410957 Sigma-Aldrich3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: IBMX

Primary Target: cAMP and cGMP phosphodiesterases

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
28822-58-4	C₁₀H₁₄N₄O₂

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
410957-1GMCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 gm	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
410957-250MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	250 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
Catalogue Number	410957
Brand Family	Calbiochem®
Synonyms	IBMX

References
References	Hube, F., et al. 1999. Horm. Metab. Res. 31, 359. Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373. Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119. Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876. Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95. Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150. Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

References

Hube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

Product Information
CAS number	28822-58-4
ATP Competitive	N
Form	White solid
Hill Formula	C₁₀H₁₄N₄O₂
Chemical formula	C₁₀H₁₄N₄O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).

Biological Information
Primary Target	cAMP and cGMP phosphodiesterases
Primary Target IC<sub>50</sub>	2-50 µM against cAMP and cGMP phosphodiesterases
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	ZD8500000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
410957-1GMCN	04055977211139
410957-250MGCN	04055977211146

Documentation

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem 分析证书

标题	批号
410957	输入批号

参考

参考信息概述
Hube, F., et al. 1999. Horm. Metab. Res. 31, 359. Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373. Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119. Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876. Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95. Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150. Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

参考信息概述

小册子

标题
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-July-2013 JSW
Synonyms	IBMX
Description	A non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.
Form	White solid
CAS number	28822-58-4
RTECS	ZD8500000
Chemical formula	C₁₀H₁₄N₄O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (100 mM), Ethanol (10 mg/ml), or Methanol (50 mg/ml). Heating may be required to achieve complete solubilization.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
Toxicity	Standard Handling
References	Hube, F., et al. 1999. Horm. Metab. Res. 31, 359. Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373. Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119. Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876. Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95. Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150. Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors

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