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288104 Sigma-Aldrich2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem

Cell-permeable, non-competitive adenylate cyclase inhibitor (IC₅₀ = 3 µM), that binds to the adenosine P1 binding site.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 2ʹ,5ʹ-dd-Ado

Primary Target: adenylate cyclase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
6698-26-6	C₁₀H₁₃N₅O₂

价格及供货情况

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Description
Overview	Cell-permeable, non-competitive adenylate cyclase inhibitor (IC₅₀ = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of β-adrenergic agents.
Catalogue Number	288104
Brand Family	Calbiochem®
Synonyms	2ʹ,5ʹ-dd-Ado

References
References	Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487. Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331. Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848. Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708. Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103. Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681. Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

References

Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

Product Information
CAS number	6698-26-6
ATP Competitive	N
Form	White solid
Hill Formula	C₁₀H₁₃N₅O₂
Chemical formula	C₁₀H₁₃N₅O₂
HS Code	2934 20 90
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	adenylate cyclase
Primary Target IC<sub>50</sub>	3 µM against adenylate cyclase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
288104-1MGCN	04055977197914

Documentation

2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem 分析证书

标题	批号
288104	输入批号

参考

参考信息概述
Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487. Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331. Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848. Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708. Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103. Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681. Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

参考信息概述

小册子

标题
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-June-2008 RFH
Synonyms	2ʹ,5ʹ-dd-Ado
Description	Membrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC₅₀ = 3 µM for detergent solubilized rat brain membranes; IC₅₀ = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC₅₀ = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of β-adrenergic agents.
Form	White solid
CAS number	6698-26-6
Chemical formula	C₁₀H₁₃N₅O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
References	Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487. Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331. Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848. Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708. Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103. Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681. Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Adenylate Cyclase Inhibitors

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