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441251
Sigma-Aldrichα₂-Macroglobulin, Human Plasma - Calbiochem
A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.
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α₂-Macroglobulin, Human Plasma - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
Catalogue Number
441251
Brand Family
Calbiochem®
Synonyms
α₂M, α₂MG
References
References
Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236. Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919. Boisset, N., et al. 1992. J. Struct. Biol.108, 221. Barrett, A.J. 1980. Methods Enzymol.80, 737.
Product Information
ATP Competitive
N
Form
Lyophilized
Formulation
Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236. Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919. Boisset, N., et al. 1992. J. Struct. Biol.108, 221. Barrett, A.J. 1980. Methods Enzymol.80, 737.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
06-August-2008 RFH
Synonyms
α₂M, α₂MG
Description
A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
Form
Lyophilized
Formulation
Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
Source
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity
≥95% by SDS-PAGE
Solubility
Aqueous buffers
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236. Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919. Boisset, N., et al. 1992. J. Struct. Biol.108, 221. Barrett, A.J. 1980. Methods Enzymol.80, 737.
