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100068 Sigma-Aldrich17-AAG - CAS 75747-14-7 - Calbiochem

A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus.

17-AAG - CAS 75747-14-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
数据表
Data Sheet
用户指南

同义词: NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin

Primary Target: Hsp90

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
75747-14-7	C₃₁H₄₃N₃O₈

价格及供货情况

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Description
Overview	A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC₅₀ = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC₅₀ = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC₅₀ = 45 nM), mutant p53 (EC₅₀ = 62 nM), Raf-1 (EC₅₀ = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
Catalogue Number	100068
Brand Family	Calbiochem®
Synonyms	NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin

References
References	Basso, A.D., et al. 2002. Oncogene 21, 1159. Clarke, P.A., et al. 2002. Oncogene 19, 4125. Clarke, P.A., et al. 2000. Oncogene 19, 4125. Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273. Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

Product Information
CAS number	75747-14-7
ATP Competitive	N
Form	Purple solid
Hill Formula	C₃₁H₄₃N₃O₈
Chemical formula	C₃₁H₄₃N₃O₈
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Hsp90
Primary Target IC<sub>50</sub>	EC50 = 7.2 µM for Hsp90
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
100068-500UGCN	04055977226881

Documentation

17-AAG - CAS 75747-14-7 - Calbiochem 分析证书

标题	批号
100068	输入批号

参考

参考信息概述
Basso, A.D., et al. 2002. Oncogene 21, 1159. Clarke, P.A., et al. 2002. Oncogene 19, 4125. Clarke, P.A., et al. 2000. Oncogene 19, 4125. Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273. Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

数据表

标题
Data Sheet 1.00068.0500

用户指南

标题
Pack insert Bolton Broth Selective Supplement 1.00079.0010

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-October-2007 RFH
Synonyms	NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
Description	A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC₅₀ = 7.2 µM) and regulates its function. Reported to induce apoptosis and exhibit anti-tumor properties (IC₅₀ = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC₅₀ = 45 nM), mutant p53, (EC₅₀ = 62 nM), Raf-1 (EC₅₀ = 80 nM), and Akt. Hence, inhibits the Ras/Raf/MEK and PI3-Kinase signaling pathways. Shown to sensitize cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380), and down-regulates vascular endothelial factor expression.
Form	Purple solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	75747-14-7
Chemical formula	C₃₁H₄₃N₃O₈
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml) or Methanol (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Basso, A.D., et al. 2002. Oncogene 21, 1159. Clarke, P.A., et al. 2002. Oncogene 19, 4125. Clarke, P.A., et al. 2000. Oncogene 19, 4125. Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273. Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Heat Shock Protein Inhibitors

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