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385581 Sigma-Aldrich11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

The 11beta-HSD1 Inhibitor, 10j, also referenced under CAS 1009373-58-3, controls the biological activity of 11beta-HSD1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1009373-58-3	C₂₆H₃₃BrN₂O₃

价格及供货情况

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Description
Overview	A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC₅₀ of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
Catalogue Number	385581
Brand Family	Calbiochem®

References
References	Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.

Product Information
CAS number	1009373-58-3
Form	White solid
Hill Formula	C₂₆H₃₃BrN₂O₃
Chemical formula	C₂₆H₃₃BrN₂O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
385581-10MGCN	04055977190298

Documentation

11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem 分析证书

标题	批号
385581	输入批号

参考

参考信息概述
Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-April-2011 RFH
Description	A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC₅₀ of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10 mg/kg in animals p.o.) results in an ~80% reduction in the concentration of plasma cortisol over vehicle treated controls.
Form	White solid
CAS number	1009373-58-3
Chemical formula	C₂₆H₃₃BrN₂O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSL (100 mg/ml)
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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