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149101 Sigma-Aldrich1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: ACPC

Primary Target: Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
22059-21-8	C₄H₇NO₂

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
149101-1GMCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 gm	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
Catalogue Number	149101
Brand Family	Calbiochem®
Synonyms	ACPC

References
References	Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527. Zapata, A., et al. 1996. NeuroReport 7, 397. Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393. Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937. Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992. Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115. Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

References

Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
Zapata, A., et al. 1996. NeuroReport 7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

Product Information
CAS number	22059-21-8
ATP Competitive	N
Form	Crystalline solid
Hill Formula	C₄H₇NO₂
Chemical formula	C₄H₇NO₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

Biological Information
Primary Target	Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
Primary Target IC<sub>50</sub>	38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
Purity	≥ 98% by TLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	GZ1110000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
149101-1GMCN	07790788059590
149101-250MGCN	04055977207521

Documentation

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem 分析证书

标题	批号
149101	输入批号

参考

参考信息概述
Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527. Zapata, A., et al. 1996. NeuroReport 7, 397. Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393. Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937. Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992. Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115. Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

参考信息概述

小册子

标题
Excitotoxic Glutamate Analogs Technical Bulletin
Pathways and Biomarkers of Glutamatergic Synapse Flyer

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-April-2008 RFH
Synonyms	ACPC
Description	A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks ³H-glycine binding to rat forebrain membranes (IC₅₀ = 38 nM).
Form	Crystalline solid
CAS number	22059-21-8
RTECS	GZ1110000
Chemical formula	C₄H₇NO₂
Structure formula
Purity	≥ 98% by TLC
Solubility	H₂O (40 mg/ml). May require heating and sonication to achieve complete solubilization.
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Irritant
References	Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527. Zapata, A., et al. 1996. NeuroReport 7, 397. Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393. Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937. Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992. Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115. Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Agonists > Glutamate Receptor Agonists

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