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A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
Catalogue Number
676777
Brand Family
Calbiochem®
Synonyms
L-Type Calcium Channel Blocker V
References
References
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23. Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027. Janis, R., et al. 1987. Adv. Drug Res.16, 309.
Toxic by inhalation, in contact with skin and if swallowed.
S Phrase
S: 22-36/37/39-45
Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
676777-100MGCN
07790788052331
Documentation
(±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem MSDS
(±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem 分析证书
标题
批号
676777
参考
参考信息概述
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23. Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027. Janis, R., et al. 1987. Adv. Drug Res.16, 309.
Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience25, 11542-11552.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
19-May-2008 RFH
Synonyms
L-Type Calcium Channel Blocker V
Description
A derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
Form
White solid
CAS number
152-11-4
RTECS
YV8320000
Chemical formula
C₂₇H₃₈N₂O₄ · HCl
Structure formula
Purity
≥99% by titration (with perchloric acid)
Solubility
H₂O (70 mg/ml), Ethanol, or Methanol (50 mg/ml)
Storage
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
Toxicity
Toxic
Merck USA index
14, 9950
References
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23. Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027. Janis, R., et al. 1987. Adv. Drug Res.16, 309.
Citation
Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience25, 11542-11552.
