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Recombinant, human α-synuclein expressed in E. coli. α-Synuclein is an acidic neuronal protein of 140 amino acids (amino acid residues 1 -140). This enzyme has been implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells.
Catalogue Number
575001
Brand Family
Calbiochem®
Synonyms
NACP
References
References
Kahle, P.J, et al. 2001. Am. J. Pathol.159, 2215. Kim, J. 1997. Mol. Cells7, 78. Paik, S.R. 1997. Arch. Biochem. Biophys.344, 325. Jakes, R., et al. 1994. FEBS Lett.345, 27. Ueda, K., et al. 1993. Proc. Natl. Acad. Sci. USA90, 11282.
Product Information
Form
Liquid
Formulation
In 100 mM NaCl, 20 mM Tris-HCl, 1 mM MgCl₂, pH 7.5.
Kahle, P.J, et al. 2001. Am. J. Pathol.159, 2215. Kim, J. 1997. Mol. Cells7, 78. Paik, S.R. 1997. Arch. Biochem. Biophys.344, 325. Jakes, R., et al. 1994. FEBS Lett.345, 27. Ueda, K., et al. 1993. Proc. Natl. Acad. Sci. USA90, 11282.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
12-September-2008 RFH
Synonyms
NACP
Description
Recombinant, human α-synuclein expressed in E. coli. An acidic neuronal protein consisting of 140 amino acids that has been implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. Also reported to be an important regulatory component of vesicular transport in neuronal cells. The apparent molecular weight by SDS-PAGE is ~19-20 kDa.
Form
Liquid
Formulation
In 100 mM NaCl, 20 mM Tris-HCl, 1 mM MgCl₂, pH 7.5.
Concentration Label
Please refer to vial label for lot-specific concentration
Purity
≥95% by SDS-PAGE
Storage
Avoid freeze/thaw
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C).
Toxicity
Standard Handling
References
Kahle, P.J, et al. 2001. Am. J. Pathol.159, 2215. Kim, J. 1997. Mol. Cells7, 78. Paik, S.R. 1997. Arch. Biochem. Biophys.344, 325. Jakes, R., et al. 1994. FEBS Lett.345, 27. Ueda, K., et al. 1993. Proc. Natl. Acad. Sci. USA90, 11282.
