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Recombinant, human α-synuclein containing an A53T mutation and expressed in E. coli. A point mutant (A53T) of α-synuclein gene that has been linked to autosomal dominant early-onset Parkinson’s disease (PD).
Catalogue Number
575003
Brand Family
Calbiochem®
References
References
Lashuel, H.A., et al. 2002. J. Mol. Biol.322, 1089. Park, S.M., et al. 2002. Blood100, 2506. Polymeropoulos, M.H., et al. 1997. Science276, 2045.
α-Synuclein A53T, Human, Recombinant, E. coli 分析证书
标题
批号
575003
参考
参考信息概述
Lashuel, H.A., et al. 2002. J. Mol. Biol.322, 1089. Park, S.M., et al. 2002. Blood100, 2506. Polymeropoulos, M.H., et al. 1997. Science276, 2045.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
12-September-2008 RFH
Description
Recombinant, human α-synuclein containing an A53T mutation and expressed in E. coli. α-synuclein is an acidic neuronal protein of 140 amino acids that has been implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. α-Synuclein (A53T) is a point mutant of the α-synuclein gene that has been linked to autosomal dominant early onset Parkinson's Disease (PD). The apparent molecular weight on SDS-PAGE is ~19-20 kDa.
Form
Liquid
Formulation
In 100 mM NaCl, 20 mM Tris-HCl, pH 7.5.
Concentration Label
Please refer to vial label for lot-specific concentration
Purity
≥95% by SDS-PAGE
Storage
Avoid freeze/thaw
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C).
Toxicity
Standard Handling
References
Lashuel, H.A., et al. 2002. J. Mol. Biol.322, 1089. Park, S.M., et al. 2002. Blood100, 2506. Polymeropoulos, M.H., et al. 1997. Science276, 2045.
