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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565764 Sigma-Aldrichγ-Secretase Substrate, Fluorogenic - Calbiochem

An internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: NMA-GGVVIATVK(DNP)-DRDRDR-NH₂

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概述

Replacement Information

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Description
Overview	An internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase. Shown to be sensitive and useful for assaying γ-secretase activity. The proteolysis at the Aβ₄₀-, Aβ₄₂-, and Aβ₄₃-generating cleavage sites results in enhanced fluorescence.
Catalogue Number	565764
Brand Family	Calbiochem®
Synonyms	NMA-GGVVIATVK(DNP)-DRDRDR-NH₂

References
References	Farmery, M.R., et al. 2003. J. Biol. Chem. 278, 24277.

Product Information
ATP Competitive	N
Form	Yellow Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₇₀H₁₁₆N₂₆O₁₈
Chemical formula	C₇₀H₁₁₆N₂₆O₁₈
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	γ-secretase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	NMA-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(DNP)-D-Arg-D-Arg-D-Arg-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with a stream of inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565764-1MGCN	04055977267730

Documentation

γ-Secretase Substrate, Fluorogenic - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Substrate, Fluorogenic - Calbiochem 分析证书

标题	批号
565764	输入批号

参考

参考信息概述
Farmery, M.R., et al. 2003. J. Biol. Chem. 278, 24277.

引用

标题

Vorobyeva, A, et al. (2014) Cyclopamine Modulates Gamma-Secretase Mediated Cleavage of Amyloid Precursor Protein by Altering its Subcellular Trafficking and Lysosomal Degradation. J. Biol. Chemistry 289, 33258.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-September-2008 RFH
Synonyms	NMA-GGVVIATVK(DNP)-DRDRDR-NH₂
Description	An internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase. Shown to be sensitive and useful for assaying γ-secretase activity. The proteolysis at the Aβ₄₀-, Aβ₄₂-, and Aβ₄₃-generating cleavage sites results in enhanced fluorescence. Excitation max.: ~355 nm; emission max.: ~440 nm.
Form	Yellow Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Recommended reaction conditions	50 mM Tris-HCl, pH 6.8, 2 mM EDTA, 0.25% CHAPSO (w/v), 8 µM substrate, 37°C.
Chemical formula	C₇₀H₁₁₆N₂₆O₁₈
Peptide Sequence	NMA-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(DNP)-D-Arg-D-Arg-D-Arg-NH₂
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml) or 5% Acetic acid
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with a stream of inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Farmery, M.R., et al. 2003. J. Biol. Chem. 278, 24277.
Citation	Vorobyeva, A, et al. (2014) Cyclopamine Modulates Gamma-Secretase Mediated Cleavage of Amyloid Precursor Protein by Altering its Subcellular Trafficking and Lysosomal Degradation. J. Biol. Chemistry 289, 33258.

种类

Life Science Research > Inhibitors and Biochemicals

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