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565789 Sigma-Aldrichγ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem

This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine

Primary Target: γ-secretase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
209984-56-5	C₂₆H₂₃F₂N₃O₃

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
565789-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
565789-500UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	500 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ₄₀ levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC₅₀ = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and Apc^Min mouse models (10 µmol/kg, i.p).
Catalogue Number	565789
Brand Family	Calbiochem®
Synonyms	(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine

References
References	Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341.

Product Information
CAS number	209984-56-5
ATP Competitive	N
Form	White solid
Hill Formula	C₂₆H₂₃F₂N₃O₃
Chemical formula	C₂₆H₂₃F₂N₃O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	γ-secretase
Primary Target IC<sub>50</sub>	1.7 nM inhibiting Notch processing in SupT1 cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565789-1MGCN	04055977191837
565789-500UGCN	04055977191844

Documentation

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem 分析证书

标题	批号
565789	输入批号

参考

参考信息概述
Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341.

引用

标题

Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2012 RFH
Synonyms	(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
Description	A cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ₄₀ levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC₅₀ = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and Apc^Min mouse models (10 µmol/kg, i.p).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	209984-56-5
Chemical formula	C₂₆H₂₃F₂N₃O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
Citation	Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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