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565773 Sigma-Aldrichγ-Secretase Inhibitor XII - Calbiochem

γ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.

γ-Secretase Inhibitor XII - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Z-IL-CHO

Primary Target: Aβ40 in vitro

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₀H₃₀N₂O₄

价格及供货情况

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Description
Overview	A cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ₄₀ IC₅₀ = 7.9 µM; Aβ₄₂ IC₅₀ = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ₄₀ IC₅₀ = 11.5 µM; Aβ₄₂ IC₅₀ = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
Catalogue Number	565773
Brand Family	Calbiochem®
Synonyms	Z-IL-CHO

References
References	Weijzen, S., et al. 2002. Nat. Med. 8, 979. McLendon, C., et al. 2000. FASEB J. 14, 2383.

Product Information
ATP Competitive	N
Form	White solid
Hill Formula	C₂₀H₃₀N₂O₄
Chemical formula	C₂₀H₃₀N₂O₄
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	γ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.

Biological Information
Primary Target	Aβ40 in vitro
Primary Target IC<sub>50</sub>	7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Ile-Leu-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565773-5MGCN	04055977267860

Documentation

γ-Secretase Inhibitor XII - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Inhibitor XII - Calbiochem 分析证书

标题	批号
565773	输入批号

参考

参考信息概述
Weijzen, S., et al. 2002. Nat. Med. 8, 979. McLendon, C., et al. 2000. FASEB J. 14, 2383.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-September-2008 RFH
Synonyms	Z-IL-CHO
Description	A cell-permeable, reversible dipeptide aldehyde that reduces amyloid-β protein (Aβ) production by blocking γ-secretase activity in vitro (Aβ₄₀ IC₅₀ = 7.9 µM; Aβ₄₂ IC₅₀ = 7.6 µM) and in cultured cells that stably over-express APP695 (Aβ₄₀ IC₅₀ = 11.5 µM; Aβ₄₂ IC₅₀ = 8.3 µM). Also shown to block the generation of γCTF (γ-secretase-generated carboxy-terminal fragment).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₀H₃₀N₂O₄
Peptide Sequence	Z-Ile-Leu-CHO
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Weijzen, S., et al. 2002. Nat. Med. 8, 979. McLendon, C., et al. 2000. FASEB J. 14, 2383.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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