数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565770 Sigma-Aldrichγ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem

Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
数据表
Data Sheet
Citations

同义词: DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester

Primary Target: Aβ_total

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
208255-80-5	C₂₃H₂₆F₂N₂O₄

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
565770-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
565770-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable dipeptide that suppresses Aβ production by blocking γ-secretase (Aβ_total IC₅₀ = 115 nM, Aβ₄₂ IC₅₀ = 200 nM). Prevents Aβ₃₄ generation in murine N2a cells and hAPP/hBACE-1 transfected human HEK 293 cells. Reported to be functionally active in both HEK 293 cells and neuronal cultures without affecting the secretion of amyloid-β precursor protein (APP). Also shown to lower Aβ levels acutely in APP-transgenic mice. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice. A 25 mM (5 mg/462 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565784) in DMSO is also available.
Catalogue Number	565770
Brand Family	Calbiochem®
Synonyms	DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester

References
References	Morohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670. Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555. Oddo, S., et al. 2004. Neuron 43, 321. Dovey, H.F., et al. 2001. J. Neurochem. 76, 173. Sastre, M., et al. 2001. EMBO Rep. 2, 835. Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

Product Information
CAS number	208255-80-5
ATP Competitive	N
Form	Lyophilized
Hill Formula	C₂₃H₂₆F₂N₂O₄
Chemical formula	C₂₃H₂₆F₂N₂O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Aβ_total
Primary Target IC<sub>50</sub>	115 nM suppressing Aβtotal production; 200 nM suppressing Aβ42 production
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565770-10MGCN	04055977267778
565770-5MGCN	07790788059941

Documentation

γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem 分析证书

标题	批号
565770	输入批号

参考

参考信息概述
Morohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670. Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555. Oddo, S., et al. 2004. Neuron 43, 321. Dovey, H.F., et al. 2001. J. Neurochem. 76, 173. Sastre, M., et al. 2001. EMBO Rep. 2, 835. Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

数据表

标题
Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

引用

标题

Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.

Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-November-2007 JSW
Synonyms	DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
Description	A cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC₅₀ = 115 nM; Aβ₄₂ IC₅₀ = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of an ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP₆₉₅. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
Form	Lyophilized
Intert gas (Yes/No)	Packaged under inert gas
CAS number	208255-80-5
Chemical formula	C₂₃H₂₆F₂N₂O₄
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Morohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670. Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555. Oddo, S., et al. 2004. Neuron 43, 321. Dovey, H.F., et al. 2001. J. Neurochem. 76, 173. Sastre, M., et al. 2001. EMBO Rep. 2, 835. Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
Citation	Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,. Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

此产品已添加到您的购物车。