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			96-Well Plate

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565761 Sigma-Aldrichγ-Secretase Inhibitor IV - Calbiochem

The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor IV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal

Primary Target: Aβ_x-40

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₅H₂₆N₂O₃

价格及供货情况

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Description
Overview	A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
Catalogue Number	565761
Brand Family	Calbiochem®
Synonyms	2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal

References
References	Green, K.N., et al. 2002. J. Physiol. 541.3, 1013. Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Hill Formula	C₂₅H₂₆N₂O₃
Chemical formula	C₂₅H₂₆N₂O₃
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	Aβ_x-40
Primary Target IC<sub>50</sub>	ED50 = 2.6 µM for Aβx-40
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	2-Naphthoyl-Val-Phe-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565761-1MGCN	04055977267716

Documentation

γ-Secretase Inhibitor IV - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

γ-Secretase Inhibitor IV - Calbiochem 分析证书

标题	批号
565761	输入批号

参考

参考信息概述
Green, K.N., et al. 2002. J. Physiol. 541.3, 1013. Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-September-2008 RFH
Synonyms	2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
Description	A cell-permeable, reversible inhibitor of γ-secretase. Inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.
Form	White lyophilized solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₅H₂₆N₂O₃
Peptide Sequence	2-Naphthoyl-Val-Phe-CHO
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Green, K.N., et al. 2002. J. Physiol. 541.3, 1013. Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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